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    Slc49a4 solute carrier family 49 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc49a4provided by RGD
    Official Full Name
    solute carrier family 49 member 4provided by RGD
    Primary source
    RGD:1310939
    See related
    EnsemblRapid:ENSRNOG00000002240 AllianceGenome:RGD:1310939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dirc2
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in pyridoxine transport. Predicted to be located in lysosomal membrane. Predicted to be active in intracellular membrane-bounded organelle and membrane. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human SLC49A4 (solute carrier family 49 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 159.7), Heart (RPKM 142.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc49a4 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78500918..78574205)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64995629..65068929)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68198709..68272766)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 14 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene HSPB1 associated protein 1 Neighboring gene uncharacterized LOC108352343 Neighboring gene metastasis associated 1 family, member 2, pseudogene 1 Neighboring gene semaphorin 5B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21). Bodmer D, et al. Hum Mol Genet, 2002 Mar 15. PMID 11912179
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in pyridoxine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyridoxine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 49 member 4
    Names
    disrupted in renal carcinoma 2 homolog
    disrupted in renal carcinoma protein 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012017.1 → NP_001012017.1  solute carrier family 49 member 4

      See identical proteins and their annotated locations for NP_001012017.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081960
      UniProtKB/Swiss-Prot
      Q66H95
      Related
      ENSRNOP00000003048.4, ENSRNOT00000003048.7
      Conserved Domains (1) summary
      cd06174
      Location:66 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      78500918..78574205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088342.2 → XP_038944270.1  solute carrier family 49 member 4 isoform X1

      UniProtKB/TrEMBL
      A6IRF5
      Conserved Domains (1) summary
      cl28910
      Location:29 → 333
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H95.1 GenPept UniProtKB/Swiss-Prot:Q66H95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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