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    Wdr41 WD repeat domain 41 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr41provided by RGD
    Official Full Name
    WD repeat domain 41provided by RGD
    Primary source
    RGD:1306363
    See related
    EnsemblRapid:ENSRNOG00000025462 AllianceGenome:RGD:1306363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of autophagy. Predicted to be located in cytoplasm. Predicted to be part of Atg1/ULK1 kinase complex and guanyl-nucleotide exchange factor complex. Orthologous to human WDR41 (WD repeat domain 41). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 78.6), Brain (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr41 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (27957453..28008573)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26222797..26273849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (24668108..24717280)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350223 Neighboring gene orthopedia homeobox Neighboring gene phosphodiesterase 8B Neighboring gene uncharacterized LOC134485577 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Sullivan PM, et al. Acta Neuropathol Commun, 2016 May 18. PMID 27193190, Free PMC Article
    2. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Yang M, et al. Sci Adv, 2016 Sep. PMID 27617292, Free PMC Article
    3. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article
    4. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395597.2 → NP_001382526.1  WD repeat-containing protein 41 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZYE1, B2RYI7
      Related
      ENSRNOP00000061347.3, ENSRNOT00000067022.6
      Conserved Domains (2) summary
      sd00039
      Location:87 → 133
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:38 → 350
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001395716.1 → NP_001382645.1  WD repeat-containing protein 41 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZYE1, F7ETI3
      Related
      ENSRNOP00000031387.7, ENSRNOT00000036748.7
      Conserved Domains (2) summary
      sd00039
      Location:87 → 132
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:38 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      27957453..28008573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102530.2 → XP_038958458.1  WD repeat-containing protein 41 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYE1
      Related
      ENSRNOP00000084562.2, ENSRNOT00000109022.2
      Conserved Domains (2) summary
      sd00039
      Location:76 → 122
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:27 → 339
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108541.1: Suppressed sequence

      Description
      NM_001108541.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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