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    Nnmt nicotinamide N-methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 18113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nnmtprovided by MGI
    Official Full Name
    nicotinamide N-methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1099443
    See related
    Ensembl:ENSMUSG00000032271 AllianceGenome:MGI:1099443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables nicotinamide N-methyltransferase activity. Involved in nicotinamide metabolic process; positive regulation of gluconeogenesis; and positive regulation of protein deacetylation. Acts upstream of or within methylation. Located in cytosol. Is expressed in brown fat. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human NNMT (nicotinamide N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 9.1), subcutaneous fat pad adult (RPKM 7.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nnmt in Genome Data Viewer
    Location:
    9 A5.3; 9 26.45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48448905..48518958, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48538002..48607655, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9759 Neighboring gene predicted gene 5617 Neighboring gene STARR-seq mESC enhancer starr_24069 Neighboring gene RNA binding motif protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E5067 Neighboring gene STARR-seq mESC enhancer starr_24071 Neighboring gene STARR-seq mESC enhancer starr_24072 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:48458381-48458564 Neighboring gene predicted gene, 53521 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene predicted gene, 32280

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease. Zhen X, et al. PeerJ, 2023. PMID 37953778, Free PMC Article
    2. Hyperhomocysteinemia does not affect global DNA methylation and nicotinamide N-methyltransferase expression in mice. Bromberg A, et al. J Psychopharmacol, 2011 Jul. PMID 21169389
    3. NNMT activation can contribute to the development of fatty liver disease by modulating the NAD (+) metabolism. Komatsu M, et al. Sci Rep, 2018 Jun 5. PMID 29872122, Free PMC Article
    4. Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism. Hong S, et al. Biochemistry, 2018 Oct 9. PMID 30226369
    5. Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance. Brachs S, et al. Diabetes, 2019 Mar. PMID 30552109

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease.
      Title: Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease.
    2. Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte cell line.
      Title: Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte cell line.
    3. Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.
      Title: Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.
    4. Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes.
      Title: Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes.
    5. NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner.
      Title: NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner.
    6. Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-beta1/Smad3 pathway.
      Title: Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway.
    7. ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development.
      Title: ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development.
    8. Glucose availability regulates Nnmt expression in adipocytes.
      Title: Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes.
    9. These data indicate that NNMT links the NAD(+) and methionine metabolic pathways and promotes liver steatosis and fibrosis.
      Title: NNMT activation can contribute to the development of fatty liver disease by modulating the NAD (+) metabolism.
    10. by co-opting the enzymes of the methionine cycle, Nnmt aids the recycling of homocysteine to S-adenosylmethionine for another round of methylation.
      Title: Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nicotinamide N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinamide N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nicotinamide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nicotinamide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinamide N-methyltransferase
    NP_001297991.1
    NP_001396191.1
    NP_001396192.1
    NP_001396193.1
    NP_001396194.1
    NP_001396195.1
    NP_001396196.1
    NP_035054.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311062.2 → NP_001297991.1  nicotinamide N-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113548
      Consensus CDS
      CCDS80991.1
      UniProtKB/TrEMBL
      D3YX59
      Related
      ENSMUSP00000112381.2, ENSMUST00000119426.2
      Conserved Domains (1) summary
      cl17173
      Location:2 → 137
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001409262.1 → NP_001396191.1  nicotinamide N-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113548
      UniProtKB/Swiss-Prot
      O55239

    3. NM_001409263.1 → NP_001396192.1  nicotinamide N-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113548
      UniProtKB/Swiss-Prot
      O55239

    4. NM_001409264.1 → NP_001396193.1  nicotinamide N-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113548
      UniProtKB/TrEMBL
      D3YX59

    5. NM_001409265.1 → NP_001396194.1  nicotinamide N-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113548, AC160992

    6. NM_001409266.1 → NP_001396195.1  nicotinamide N-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113548
      UniProtKB/TrEMBL
      Q9D9X3

    7. NM_001409267.1 → NP_001396196.1  nicotinamide N-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113548

    8. NM_010924.4 → NP_035054.1  nicotinamide N-methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_035054.1

      Status: VALIDATED

      Source sequence(s)
      AC113548
      Consensus CDS
      CCDS23157.1
      UniProtKB/Swiss-Prot
      O55239
      Related
      ENSMUSP00000034808.6, ENSMUST00000034808.12
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      48448905..48518958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55239.1 GenPept UniProtKB/Swiss-Prot:O55239

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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