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    Vmn2r1 vomeronasal 2, receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 56544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vmn2r1provided by MGI
    Official Full Name
    vomeronasal 2, receptor 1provided by MGI
    Primary source
    MGI:MGI:3645892
    See related
    Ensembl:ENSMUSG00000027824 AllianceGenome:MGI:3645892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V2r83; Casrl1; EG56544; Gm34462
    Summary
    Enables G protein-coupled olfactory receptor activity. Acts upstream of or within neuron differentiation. Located in cell cortex. Is expressed in Grueneberg ganglion and nasal septum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Vmn2r1 in Genome Data Viewer
    Location:
    3; 3 E1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63962008..64142935)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (64078172..64220847)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:63768480-63768744 Neighboring gene solute carrier family 33 (acetyl-CoA transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E2666 Neighboring gene STARR-seq mESC enhancer starr_07841 Neighboring gene guanine monophosphate synthetase Neighboring gene vomeronasal 2, receptor, pseudogene 3 Neighboring gene predicted gene, 22165 Neighboring gene vomeronasal 2, receptor 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_07842 Neighboring gene STARR-seq mESC enhancer starr_07843 Neighboring gene vomeronasal 2, receptor 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07845 Neighboring gene vomeronasal 2, receptor 3 Neighboring gene predicted gene, 23897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coordinated coexpression of two vomeronasal receptor V2R genes per neuron in the mouse. Ishii T, et al. Mol Cell Neurosci, 2011 Feb. PMID 21112400
    2. Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice. Gao F, et al. J Gerontol A Biol Sci Med Sci, 2024 Jul 1. PMID 38447057
    3. Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ. Martini S, et al. J Neurosci, 2001 Feb 1. PMID 11157070, Free PMC Article
    4. Subpopulations of vomeronasal sensory neurons with coordinated coexpression of type 2 vomeronasal receptor genes are differentially dependent on Vmn2r1. Akiyoshi S, et al. Eur J Neurosci, 2018 Apr. PMID 29465786, Free PMC Article
    5. Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice. Dietschi Q, et al. Sci Adv, 2022 Nov 18. PMID 36383665, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice.
      Title: Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice.
    2. great majority of vomeronasal sensory neurons that express intact V2rf2 coexpress Vmn2r1 immunoreactivity
      Title: Coordinated coexpression of two vomeronasal receptor V2R genes per neuron in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled olfactory receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal type-2 receptor 1
    Names
    V2Rx
    calcium-sensing receptor like 1
    pheromone receptor V2Rx
    putative pheromone receptor V2R1
    putative pheromone receptor V2R2
    tissue-type vomeronasal neurons putative pheromone receptor V2
    vomeronasal receptor Vmn2r1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384924.1 → NP_001371853.1  vomeronasal type-2 receptor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126803
      UniProtKB/Swiss-Prot
      O70410, Q0WXF6
      Conserved Domains (3) summary
      cd15280
      Location:544 → 796
      7tmC_V2R-like; vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06364
      Location:1 → 463
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:471 → 524
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    2. NM_019918.2 → NP_064302.2  vomeronasal type-2 receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_064302.2

      Status: VALIDATED

      Source sequence(s)
      AC126803, AF053986
      Consensus CDS
      CCDS17384.1
      UniProtKB/Swiss-Prot
      O70410, Q0WXF6
      UniProtKB/TrEMBL
      G3X8Y6
      Related
      ENSMUSP00000029406.5, ENSMUST00000029406.6
      Conserved Domains (4) summary
      pfam00003
      Location:632 → 866
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:86 → 504
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:548 → 598
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:46 → 538
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      63962008..64142935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501757.4 → XP_006501820.1  vomeronasal type-2 receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      O70410, Q0WXF6
      Conserved Domains (3) summary
      cd15280
      Location:544 → 796
      7tmC_V2R-like; vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06364
      Location:1 → 463
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:471 → 524
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    2. XM_036163177.1 → XP_036019070.1  vomeronasal type-2 receptor 1 isoform X7

      Conserved Domains (1) summary
      cd06364
      Location:51 → 468
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    3. XM_036163176.1 → XP_036019069.1  vomeronasal type-2 receptor 1 isoform X6

      Conserved Domains (1) summary
      cd06364
      Location:51 → 467
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    4. XM_006501760.2 → XP_006501823.1  vomeronasal type-2 receptor 1 isoform X4

      Conserved Domains (1) summary
      cd06364
      Location:51 → 467
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    5. XM_036163175.1 → XP_036019068.1  vomeronasal type-2 receptor 1 isoform X5

      Conserved Domains (1) summary
      cd06364
      Location:51 → 473
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    6. XM_006501758.1 → XP_006501821.1  vomeronasal type-2 receptor 1 isoform X2

      UniProtKB/Swiss-Prot
      O70410, Q0WXF6
      Conserved Domains (3) summary
      cd15280
      Location:542 → 794
      7tmC_V2R-like; vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:469 → 522
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06364
      Location:51 → 467
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    7. XM_006501759.4 → XP_006501822.1  vomeronasal type-2 receptor 1 isoform X3

      Conserved Domains (1) summary
      cd06364
      Location:51 → 467
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    RNA

    1. XR_004941362.1 RNA Sequence

    2. XR_004941363.1 RNA Sequence

    3. XR_004941364.1 RNA Sequence

    4. XR_004941365.1 RNA Sequence

    5. XR_375555.3 RNA Sequence

    6. XR_001783721.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70410.1 GenPept UniProtKB/Swiss-Prot:O70410

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