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    Ltc4s leukotriene C4 synthase [ Mus musculus (house mouse) ]

    Gene ID: 17001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ltc4sprovided by MGI
    Official Full Name
    leukotriene C4 synthaseprovided by MGI
    Primary source
    MGI:MGI:107498
    See related
    Ensembl:ENSMUSG00000020377 AllianceGenome:MGI:107498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 93.5), mammary gland adult (RPKM 76.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ltc4s in Genome Data Viewer
    Location:
    11 B1.3; 11 30.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50127288..50129378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50236461..50238532, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29391 Neighboring gene predicted gene, 36556 Neighboring gene mannoside acetylglucosaminyltransferase 4, isoenzyme B Neighboring gene microRNA 6919 Neighboring gene STARR-seq mESC enhancer starr_29394 Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50105936-50106045 Neighboring gene STARR-seq mESC enhancer starr_29397 Neighboring gene calnexin Neighboring gene STARR-seq mESC enhancer starr_29398 Neighboring gene STARR-positive B cell enhancer ABC_E1417

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of the gene for mouse leukotriene-C4 synthase. Penrose JF, et al. Eur J Biochem, 1997 Sep 15. PMID 9342232
    2. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. Kim DC, et al. J Immunol, 2006 Apr 1. PMID 16547282
    3. Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. Shimada A, et al. Neuroscience, 2005. PMID 15730873
    4. Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase. Hevko JM, et al. J Biol Chem, 2002 Mar 1. PMID 11748223
    5. Structure and inhibition of mouse leukotriene C4 synthase. Niegowski D, et al. PLoS One, 2014. PMID 24810165, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutational and kinetic data, together with molecular simulations, suggest that phosphorylation of Ser(36) inhibits the catalytic function of LTC4S by interference with the catalytic machinery.
      Title: Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
    2. LTC4 synthase was selectively localized in the vasopressinergic magnocellular neurons of the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei and in the retrochiasmatic area.
      Title: Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain.
    3. These results suggest that LTC(4) synthase, thought to be specific for the conjugation of GSH to LTA(4), can also recognize 5-oxoETE as an electrophilic substrate.
      Title: Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase.
    4. Expression of leukotriene C4 synthase mRNA in the choroid plexus.
      Title: Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C4 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-C4 synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within leukotriene metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    leukotriene C4 synthase
    Names
    LTC4 synthase
    glutathione S-transferase LTC4
    leukotriene-C(4) synthase
    NP_001300897.1
    NP_032547.1
    XP_036012258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313968.2 → NP_001300897.1  leukotriene C4 synthase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL627187
      Consensus CDS
      CCDS83799.1
      UniProtKB/TrEMBL
      Q8K355
      Related
      ENSMUSP00000098823.3, ENSMUST00000101265.9
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 105
      MAPEG; MAPEG family

    2. NM_008521.3 → NP_032547.1  leukotriene C4 synthase isoform 1

      See identical proteins and their annotated locations for NP_032547.1

      Status: REVIEWED

      Source sequence(s)
      AL627187
      Consensus CDS
      CCDS24631.1
      UniProtKB/Swiss-Prot
      Q5SVR7, Q60860, Q9QVS1
      Related
      ENSMUSP00000099833.4, ENSMUST00000102772.4
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 124
      MAPEG; MAPEG family

    RNA

    1. NR_132732.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL627187
      Related
      ENSMUST00000125555.2

    2. NR_132733.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL627187
      Related
      ENSMUST00000221525.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50127288..50129378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156365.1 → XP_036012258.1  leukotriene C4 synthase isoform X1

      Conserved Domains (1) summary
      pfam01124
      Location:45 → 126
      MAPEG; MAPEG family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60860.1 GenPept UniProtKB/Swiss-Prot:Q60860

    Gene LinkOut

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