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    CG17239 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59224, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG17239provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042186
    Locus tag
    Dmel_CG17239
    See related
    AllianceGenome:FB:FBgn0042186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17239; SP138
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in seminal receptacle and spermatheca. Orthologous to human KLK13 (kallikrein related peptidase 13); PRSS36 (serine protease 36); and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17239 in Genome Data Viewer
    Location:
    22D5-22D5; 2-5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2251510..2252341, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2251510..2252341, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42859 Neighboring gene Serine protease 12 Neighboring gene uncharacterized protein Neighboring gene Spermathecal endopeptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Kelleher ES, et al. Mol Biol Evol, 2009 Sep. PMID 19546158, Free PMC Article
    2. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Lawniczak MK, et al. Mol Biol Evol, 2007 Sep. PMID 17573377
    3. Regional specialization, polyploidy, and seminal fluid transcripts in the Drosophila female reproductive tract. Thayer RC, et al. Proc Natl Acad Sci U S A, 2024 Oct 29. PMID 39453739,
    4. Transcriptional profiling of the sperm storage organs of Drosophila melanogaster. Prokupek AM, et al. Insect Mol Biol, 2009 Aug. PMID 19453766
    5. Divergence in Transcriptional and Regulatory Responses to Mating in Male and Female Fruitflies. Fowler EK, et al. Sci Rep, 2019 Nov 6. PMID 31695054, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17239-PA
    CG17239-PB
    NP_001259920.1
    NP_722784.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2251510..2252341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272991.1 → NP_001259920.1  uncharacterized protein Dmel_CG17239, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V675, Q9VQ98
      Conserved Domains (2) summary
      smart00020
      Location:23 → 237
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24 → 237
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_164469.2 → NP_722784.1  uncharacterized protein Dmel_CG17239, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V675, Q9VQ98
      Related
      FBpp0077482
      Conserved Domains (2) summary
      smart00020
      Location:23 → 237
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24 → 237
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ98 Q9VQ98

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