VGAT Vesicular GABA Transporter [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: VGATprovided by FlyBase
Official Full Name: Vesicular GABA Transporterprovided by FlyBase
Primary source: FLYBASE:FBgn0033911
Locus tag: Dmel_CG8394
See related: AllianceGenome:FB:FBgn0033911
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8394; CG8394.2; Dmel\CG8394; dVGAT; vGAT; Vgat; VIAAT
Summary: Predicted to enable gamma-aminobutyric acid:proton symporter activity and glycine transmembrane transporter activity. Involved in several processes, including GABAergic synaptic transmission; gamma-aminobutyric acid transport; and visual behavior. Located in synaptic vesicle membrane. Is expressed in several structures, including adult brain; ganglia; optic lobe intrinsic columnar neurons; synaptic neuropil domain; and unpaired neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and generalized epilepsy with febrile seizures plus. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14198478..14201249, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10085983..10088754, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables gamma-aminobutyric acid transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables gamma-aminobutyric acid:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, GABAergic	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual behavior	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain