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    GstE6 Glutathione S transferase E6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37111, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GstE6provided by FlyBase
    Official Full Name
    Glutathione S transferase E6provided by FlyBase
    Primary source
    FLYBASE:FBgn0063494
    Locus tag
    Dmel_CG17530
    See related
    AllianceGenome:FB:FBgn0063494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17530; CT38747; Dmel\CG17530; DmGSTE6; E6; gste6; gstE6; GSTE6
    Summary
    Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult heart; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE6 in Genome Data Viewer
    Location:
    55C7-55C7; 2-85 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18406011..18406761)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14293516..14294266)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E4 Neighboring gene Glutathione S transferase E5 Neighboring gene Glutathione S transferase E7 Neighboring gene Glutathione S transferase E8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene. Tzafestas K, et al. New Phytol, 2017 Apr. PMID 27924627
    2. Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene. Mazari AMA, et al. Biochem Biophys Rep, 2016 Mar. PMID 28955816, Free PMC Article
    3. Glutathione transferases immobilized on nanoporous alumina: flow system kinetics, screening, and stability. Kjellander M, et al. Anal Biochem, 2014 Feb 1. PMID 24157647
    4. Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster. Scian M, et al. Acta Crystallogr D Biol Crystallogr, 2015 Oct. PMID 26457432, Free PMC Article
    5. Single amino-acid mutation in a Drosoph ila melanogaster ribosomal protein: An insight in uL11 transcriptional activity. Grunchec H, et al. PLoS One, 2022. PMID 35981051, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We report a new Epsilon class protein crystal structure from Drosophila melanogaster for the glutathione transferase DmGSTE6
      Title: Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site.
    2. The structures of two epsilon-class glutathione S-transferases from Drosophila, GSTE6 and GSTE7, are reported at 2.1 and 1.5 A resolution.
      Title: Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E6
    Names
    CG17530-PA
    Glutathione-S-transferase E6
    GstE6-PA
    glutathione S-transferase
    glutathione transferase E6
    NP_611328.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18406011..18406761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137484.4 → NP_611328.1  glutathione S transferase E6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB71, Q7JZM3
      Related
      FBpp0085855
      Conserved Domains (2) summary
      cd03177
      Location:91 → 209
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      cd03045
      Location:4 → 77
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZB71 A1ZB71
    Q7JZM3 Q7JZM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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