U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    baf barrier to autointegration factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34095, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bafprovided by FlyBase
    Official Full Name
    barrier to autointegration factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031977
    Locus tag
    Dmel_CG7380
    See related
    AllianceGenome:FB:FBgn0031977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.178; BAF; CG7380; dBAF; Dmel\CG7380
    Summary
    Predicted to enable DNA binding activity. Involved in chromosome condensation and oocyte karyosome formation. Located in cytoplasm; nuclear envelope; and nucleoplasm. Is expressed in adult heart. Used to study Nestor-Guillermo progeria syndrome. Human ortholog(s) of this gene implicated in Nestor-Guillermo progeria syndrome. Orthologous to human BANF1 (BAF nuclear assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See baf in Genome Data Viewer
    Location:
    28D3-28D3; 2-29 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8029462..8030565)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8029462..8030565)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Glycine N-acyltransferase Neighboring gene Transglutaminase Neighboring gene uncharacterized protein Neighboring gene Connector of kinase to AP-1 Neighboring gene Coiled-coil domain containing 53 Neighboring gene Ribosomal protein L36A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila. Furukawa K, et al. J Struct Biol, 2007 Nov. PMID 17904382
    2. Analysis of a rare progeria variant of Barrier-to-autointegration factor in Drosophila connects centromere function to tissue homeostasis. Duan T, et al. Cell Mol Life Sci, 2023 Feb 26. PMID 36842139, Free PMC Article
    3. NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus. Lancaster OM, et al. J Cell Biol, 2007 Dec 3. PMID 18039935, Free PMC Article
    4. Two novel LEM-domain proteins are splice products of the annotated Drosophila melanogaster gene CG9424 (Bocksbeutel). Wagner N, et al. Eur J Cell Biol, 2004 Jan. PMID 15035436
    5. Localization of the Drosophila Rad9 protein to the nuclear membrane is regulated by the C-terminal region and is affected in the meiotic checkpoint. Kadir R, et al. PLoS One, 2012. PMID 22666434, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages.
      Title: Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages.
    2. Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
      Title: Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
    3. BAF phosphorylation by NHK-1 disrupts anchorage of chromosomes to the nuclear envelope, allowing karyosome formation in oocytes.
      Title: NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus.
    4. BAF disappears at an early stage due to caspase activity when apoptosis is induced by hid, and its depletion in mutants is sufficient in itself to induce cell death, suggesting it is an apoptotic mediator
      Title: BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila.
    5. BAF plays essential roles in nuclear organization and that these BAF functions are required in both M phase and interphase of the cell cycle
      Title: Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome condensation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in condensed chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    barrier to autointegration factor
    Names
    Barrier-to-Autointegration factor
    CG7380-PA
    CG7380-PB
    baf-PA
    baf-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8029462..8030565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273291.1 → NP_001260220.1  barrier to autointegration factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XE9, Q9VLU0
      UniProtKB/TrEMBL
      M9PCH8
      Conserved Domains (1) summary
      pfam02961
      Location:2 → 87
      BAF; Barrier to autointegration factor

    2. NM_135332.4 → NP_609176.1  barrier to autointegration factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XE9, Q9VLU0
      UniProtKB/TrEMBL
      M9PCH8
      Related
      FBpp0079157
      Conserved Domains (1) summary
      pfam02961
      Location:2 → 87
      BAF; Barrier to autointegration factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCH8 M9PCH8
    Q9VLU0.1 Q9VLU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous