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    Cerk Ceramide kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cerkprovided by FlyBase
    Official Full Name
    Ceramide kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037315
    Locus tag
    Dmel_CG16708
    See related
    AllianceGenome:FB:FBgn0037315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CerK; CG16708; dcerk; dCerk; Dcerk; DCERK; Dmel\CG16708
    Summary
    Enables ceramide kinase activity. Involved in ceramide metabolic process; germ cell migration; and phototransduction. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval posterior spiracle; gut section; hindgut proper primordium; and posterior spiracle primordium. Orthologous to human CERK (ceramide kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cerk in Genome Data Viewer
    Location:
    82F11-83A1; 3-47.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5358873..5368306, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1184595..1194028, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Proteasome beta7 subunit Neighboring gene long non-coding RNA:CR44103 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDase is a pan-ceramidase in Drosophila. Yuan C, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148295, Free PMC Article
    2. Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. Dasgupta U, et al. Proc Natl Acad Sci U S A, 2009 Nov 24. PMID 19892737, Free PMC Article
    3. A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons. Ghosh A, et al. PLoS Genet, 2013. PMID 24348263, Free PMC Article
    4. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. McElwain MA, et al. PLoS One, 2011. PMID 22069480, Free PMC Article
    5. Differential efficacy of genetically swapping GAL4. Chen YJ, et al. J Neurogenet, 2019 Mar-Jun. PMID 30939963

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5366990-5365369 mobile_element_type = transposon:HB{}1219

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ceramide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ceramide kinase
    Names
    CG16708-PA
    CG16708-PB
    Cerk-PA
    Cerk-PB
    NP_649530.2
    NP_730923.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5358873..5368306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169050.2 → NP_730923.1  ceramide kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNA6
      Related
      FBpp0078446
      Conserved Domains (1) summary
      PLN02204
      Location:157 → 658
      PLN02204; diacylglycerol kinase

    2. NM_141273.3 → NP_649530.2  ceramide kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649530.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNA6
      Related
      FBpp0078447
      Conserved Domains (1) summary
      PLN02204
      Location:157 → 658
      PLN02204; diacylglycerol kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95S15 Q95S15
    Q9VNA6 Q9VNA6

    Gene LinkOut

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