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    Usp5 Ubiquitin specific protease 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38375, updated on 17-Dec-2024

    Summary

    Official Symbol
    Usp5provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0035402
    Locus tag
    Dmel_CG12082
    See related
    AllianceGenome:FB:FBgn0035402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1208; CG12082; Dmel\CG12082; DmUsp5; DmUSP5; leon; Q9VZU7; usp5; USP5
    Summary
    Enables K48-linked deubiquitinase activity. Involved in several processes, including free ubiquitin chain depolymerization; negative regulation of JNK cascade; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human USP13 (ubiquitin specific peptidase 13) and USP5 (ubiquitin specific peptidase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Usp5 in Genome Data Viewer
    Location:
    63B6-63B7; 3-6 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3145405..3148358, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3145405..3148358, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase Neighboring gene BTB-protein-VII Neighboring gene NADH dehydrogenase (ubiquinone) 30 kDa subunit

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity PubMed 
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables deubiquitinase activity PubMed 
    enables deubiquitinase activity PubMed 
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in nucleus PubMed 
    is_active_in nucleus  

    General protein information

    Preferred Names
    ubiquitin specific protease 5
    Names
    CG12082-PA
    CG12082-PB
    CG12082-PC
    Usp5-PA
    Usp5-PB
    Usp5-PC
    isopeptidase T
    NP_001246589.1
    NP_001334708.1
    NP_647773.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3145405..3148358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259660.2NP_001246589.1  ubiquitin specific protease 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZU7
      Conserved Domains (5) summary
      COG5207
      Location:24825
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:333823
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14294
      Location:631674
      UBA1_UBP5_like; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase UBP5, UBP13 and similar proteins
      cd14386
      Location:696737
      UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)
      pfam02148
      Location:204278
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. NM_139516.1NP_647773.1  ubiquitin specific protease 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZU7
      Related
      FBpp0072976, FBtr0073114
      Conserved Domains (5) summary
      COG5207
      Location:24825
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:333823
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14294
      Location:631674
      UBA1_UBP5_like; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase UBP5, UBP13 and similar proteins
      cd14386
      Location:696737
      UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)
      pfam02148
      Location:204278
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    3. NM_001347744.1NP_001334708.1  ubiquitin specific protease 5, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZU7
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