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    Mtr3 Mtr3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40173, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtr3provided by FlyBase
    Official Full Name
    Mtr3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036916
    Locus tag
    Dmel_CG8025
    See related
    AllianceGenome:FB:FBgn0036916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8025; Dmel\CG8025; dMtr3; mtr3
    Summary
    Predicted to enable RNA binding activity. Involved in regulation of gene expression. Located in cytoplasm. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC6 (exosome component 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mtr3 in Genome Data Viewer
    Location:
    76D4-76D4; 3-46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19912405..19913715, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19905505..19906815, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Mi-2 Neighboring gene Suppressor of Triplolethal Neighboring gene long non-coding RNA:CR32218 Neighboring gene antisense RNA:CR43889 Neighboring gene Precursor RNA processing 3 Neighboring gene Regulatory particle non-ATPase 1 Neighboring gene Su(z)12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Graham AC, et al. Mol Biol Cell, 2006 Mar. PMID 16407406, Free PMC Article
    2. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. Kiss DL, et al. RNA, 2010 Apr. PMID 20185544, Free PMC Article
    3. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Forler D, et al. Nat Biotechnol, 2003 Jan. PMID 12483225
    4. Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3. Graham AC, et al. Traffic, 2009 May. PMID 19220816, Free PMC Article
    5. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. Lim SJ, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23358822, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mtr3
    Names
    CG8025-PA
    Mtr3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19912405..19913715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140900.5 → NP_649157.1  Mtr3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BID5, Q9VW53
      Related
      FBpp0074687
      Conserved Domains (1) summary
      cl03114
      Location:47 → 274
      RNase_PH; RNase PH-like 3'-5' exoribonucleases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BID5 Q5BID5
    Q9VW53 Q9VW53

    Gene LinkOut

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