tkv thickveins [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tkvprovided by FlyBase
Official Full Name: thickveinsprovided by FlyBase
Primary source: FLYBASE:FBgn0003716
Locus tag: Dmel_CG14026
See related: AllianceGenome:FB:FBgn0003716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Atkv; Atr25D; Brk25D; Brk25D1; Brk25D2; CG14026; Dmel\CG14026; dtfr; Dtfr; kv; l(2)04415; l(2)25Da; STK-A; str; thv; Tkv; TKV; tkv1; TKV1; tkva; TkvA
Summary: Enables BMP receptor activity and I-SMAD binding activity. Contributes to BMP binding activity. Involved in several processes, including embryonic morphogenesis; germ cell development; and imaginal disc morphogenesis. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in endosome; plasma membrane; and presynapse. Part of BMP receptor complex. Colocalizes with cytoneme. Is expressed in several structures, including anlage in statu nascendi; epithelium; gut section; head epidermis primordium; and imaginal disc. Used to study juvenile polyposis syndrome. Human ortholog(s) of this gene implicated in bone development disease (multiple); intestinal disease (multiple); and juvenile polyposis syndrome. Orthologous to several human genes including BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25D1-25D2; 2-16 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5219000..5271384, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5219000..5271384, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMP type I receptor Thickveins (Tkv) internalization is facilitated by the Drosophila homolog of Nm23 (abnormal wing disks, AWD), which is upregulated in active intestinal stem cells (ISCs) by JNK signaling. The AWD-facilitated endocytosis of Tkv is critical for the return of ISCs to quiescence, to prevent epithelial dysplasia, and for host survival during acute intestinal infection.
Title: AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis.
Gef26-Rap1 signaling pathway regulates both synaptic growth and neuronal survival by controlling BMP signaling.
Title: The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling.
Data (including data from studies using transgenic/knockout flies) suggest that nlg4 is different from nlg1-3 in that nlg4 presynaptically regulates neuromuscular junction synapse development; nlg4 appears to presynaptically regulate neuromuscular synaptic growth via BMP type I receptor signaling pathway by modulating tkv. (nlg = neuroligin; tkv = thickveins protein)
Title: Neuroligin 4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at the Drosophila neuromuscular junction.
Negative regulation of Tkv by Ube3a was conserved in mammalian cells. These results reveal a critical role for Ube3a in regulating NMJ synapse development by repressing BMP signaling. This study sheds new light onto the neuronal functions of UBE3A and provides novel perspectives for understanding the pathogenesis of UBE3A-associated disorders.
Title: Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila.
Our data reveal that the basolateral determinant Scribbled (Scrib) is required for PCV formation through optimizing BMP signaling. Scrib regulates BMP-type I receptor Thickveins (Tkv) localization at the basolateral region of PCV cells and subsequently facilitates Tkv internalization to Rab5 endosomes, where Tkv is active
Title: Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis.
Our results together demonstrate for the first time that S6KL regulates synaptic development and function by facilitating proteasomal degradation of the BMP receptor Tkv.
Title: Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins.
Thickveins (Tkv; a type I receptor of Dpp) is highly expressed in stromal cells next to Dpp-producing cells and functions to remove excess Dpp outside the stem cell niche.
Title: Wnt ligands regulate Tkv expression to constrain Dpp activity in the Drosophila ovarian stem cell niche.
BMP receptor is activated at adherens junctions in the Drosophila germline stem cell niche.
Title: Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche.
Data show that the expression of tkv correlates with the spatial pattern of BMP signaling.
Title: BMP signaling dynamics in the follicle cells of multiple Drosophila species.
Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.
Title: The interaction between two TGF-beta type I receptors plays important roles in ligand binding, SMAD activation, and gradient formation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables BMP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables BMP receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables BMP receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables I-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in amnioserosa formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior pattern specification, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell elongation involved in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in genital disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in histoblast morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of salivary gland boundary specification	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spectrosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BMP receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thickveins

Names: Activin-A-receptor-25D; BMP receptor kinase 25D; CG14026-PA; CG14026-PB; CG14026-PC; CG14026-PD; DPP receptor; Thick-vein; Thick-veins; slater; thick veins; thickvein; tkv-PA; tkv-PB; tkv-PC; tkv-PD

NP_787989.1

EC 2.7.11.30

NP_787990.1

EC 2.7.11.30

NP_787991.1

EC 2.7.11.30

NP_787992.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5219000..5271384 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_175975.2 → NP_787989.1 thickveins, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_787989.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QPJ0, Q24326, Q7KTP1

Related

FBpp0078720

Conserved Domains (4) summary

smart00467
Location:226 → 254

GS; GS motif

smart00220
Location:255 → 545

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14144
Location:258 → 550

STKc_BMPR1; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor

pfam01064
Location:69 → 159

Activin_recp; Activin types I and II receptor domain
NM_175976.2 → NP_787990.1 thickveins, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_787990.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LA64, Q9VMT1

Related

FBpp0078721

Conserved Domains (4) summary

smart00467
Location:238 → 266

GS; GS motif

smart00220
Location:267 → 557

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14144
Location:270 → 562

STKc_BMPR1; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor

pfam01064
Location:81 → 171

Activin_recp; Activin types I and II receptor domain
NM_175977.2 → NP_787991.1 thickveins, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_787991.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QPJ0, Q8IPK9

Related

FBpp0078722

Conserved Domains (4) summary

smart00467
Location:194 → 222

GS; GS motif

smart00220
Location:223 → 513

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14144
Location:226 → 518

STKc_BMPR1; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor

pfam01064
Location:37 → 127

Activin_recp; Activin types I and II receptor domain
NM_175978.2 → NP_787992.1 thickveins, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_787992.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QPJ0, Q95SI0

Related

FBpp0078723

Conserved Domains (4) summary

smart00467
Location:172 → 200

GS; GS motif

smart00220
Location:201 → 491

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14144
Location:204 → 496

STKc_BMPR1; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor

pfam01064
Location:15 → 105

Activin_recp; Activin types I and II receptor domain