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    CG1494 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1494provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031169
    Locus tag
    Dmel_CG1494
    See related
    AllianceGenome:FB:FBgn0031169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DmCG1494; Dmel\CG1494
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1494 in Genome Data Viewer
    Location:
    19F3-19F3; 1-65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21285301..21292458)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21156328..21163485)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Membrane-bound Notch regulator Neighboring gene transfer RNA:Arginine-TCG 2-2 Neighboring gene uncharacterized protein Neighboring gene ATP binding cassette subfamily A member 3 Neighboring gene mir-1007 stem loop Neighboring gene mir-2535b stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. Moulton MJ, et al. Proc Natl Acad Sci U S A, 2021 Dec 28. PMID 34949639, Free PMC Article
    2. The Drosophila Tis11 protein and its effects on mRNA expression in flies. Choi YJ, et al. J Biol Chem, 2014 Dec 19. PMID 25342740, Free PMC Article
    3. ATP-Binding Cassette (ABC) Transporter Genes Involved in Pyrethroid Resistance in the Malaria Vector Anopheles sinensis: Genome-Wide Identification, Characteristics, Phylogenetics, and Expression Profile. He Q, et al. Int J Mol Sci, 2019 Mar 20. PMID 30897799, Free PMC Article
    4. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Ren Q, et al. Nucleic Acids Res, 2007 Jan. PMID 17135193, Free PMC Article
    5. The ABC gene family in arthropods: comparative genomics and role in insecticide transport and resistance. Dermauw W, et al. Insect Biochem Mol Biol, 2014 Feb. PMID 24291285

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1494-PB
    CG1494-PC
    NP_001259763.1
    NP_608444.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21285301..21292458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272834.1 → NP_001259763.1  uncharacterized protein Dmel_CG1494, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRG3
      Conserved Domains (5) summary
      PRK14255
      Location:1371 → 1586
      PRK14255; phosphate ABC transporter ATP-binding protein; Provisional
      cd03263
      Location:541 → 761
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:541 → 848
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:263 → 480
      ABC2_membrane_3; ABC-2 family transporter protein
      cl21474
      Location:1080 → 1188
      ABC2_membrane; ABC-2 type transporter

    2. NM_134600.2 → NP_608444.2  uncharacterized protein Dmel_CG1494, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608444.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRG3
      Conserved Domains (5) summary
      PRK14255
      Location:1371 → 1586
      PRK14255; phosphate ABC transporter ATP-binding protein; Provisional
      cd03263
      Location:541 → 761
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:541 → 848
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:263 → 480
      ABC2_membrane_3; ABC-2 family transporter protein
      cl21474
      Location:1080 → 1188
      ABC2_membrane; ABC-2 type transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRG3 Q9VRG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials