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    RagA-B Ras-related GTP binding A/B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41071, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RagA-Bprovided by FlyBase
    Official Full Name
    Ras-related GTP binding A/Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037647
    Locus tag
    Dmel_CG11968
    See related
    AllianceGenome:FB:FBgn0037647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11968; Dmel\CG11968; dRagA; dRagB; Gtr1; rag; Rag; Rag A; Rag A-B; ragA; RagA; RagA/B; RagAB
    Summary
    Enables protein heterodimerization activity. Involved in several processes, including cellular response to starvation; positive regulation of TORC1 signaling; and positive regulation of cell growth. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Is expressed in adult head. Orthologous to several human genes including RRAGA (Ras related GTP binding A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RagA-B in Genome Data Viewer
    Location:
    85C1-85C1; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8982732..8984315, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4808454..4810037, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Succinyl-coenzyme A synthetase beta subunit, ADP-forming Neighboring gene uncharacterized protein Neighboring gene ichor Neighboring gene Carbonic anhydrase beta Neighboring gene uncharacterized protein Neighboring gene Enhancer of variegation 3-9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAP4K3 regulates body size and metabolism in Drosophila. Bryk B, et al. Dev Biol, 2010 Aug 1. PMID 20457147
    2. The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction. Yang S, et al. Dev Cell, 2020 Nov 9. PMID 32898476, Free PMC Article
    3. Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher. O'Farrell F, et al. PLoS Biol, 2013 Jul. PMID 23935447, Free PMC Article
    4. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Demetriades C, et al. Cell, 2014 Feb 13. PMID 24529380, Free PMC Article
    5. Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity. Jang YG, et al. Mol Cells, 2020 Aug 31. PMID 32759469, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related GTP binding A/B
    Names
    CG11968-PA
    RagA-B-PA
    Ras-related GTP binding A/B ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8982732..8984315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141593.4 → NP_649850.1  Ras-related GTP binding A/B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHJ4
      Related
      FBpp0081491
      Conserved Domains (2) summary
      cd11384
      Location:4 → 287
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
      COG1100
      Location:2 → 146
      Gem1; GTPase SAR1 family domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHJ4 Q9VHJ4

    Gene LinkOut

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