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    Cog7 Component of oligomeric golgi complex 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43547, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Cog7provided by FlyBase
    Official Full Name
    Component of oligomeric golgi complex 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0051040
    Locus tag
    Dmel_CG31040
    See related
    AllianceGenome:FB:FBgn0051040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31040; CG7880; Dmel\CG31040
    Summary
    Involved in Golgi organization; cytoskeleton-dependent cytokinesis; and protein localization to Golgi membrane. Located in acroblast. Part of Golgi transport complex. Is expressed in spermatid and spermatocyte. Used to study congenital disorder of glycosylation type IIe. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIe. Orthologous to human COG7 (component of oligomeric golgi complex 7). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Cog7 in Genome Data Viewer
    Location:
    99C7-99C7; 3-99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29930551..29933057, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25756273..25758779, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Jonah 99Ci Neighboring gene alpha-Mannosidase class I c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2B subunit alpha Neighboring gene Vacuolar protein sorting 13B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Microtubule Cytoskeleton during the Early Drosophila Spermiogenesis. Riparbelli MG, et al. Cells, 2020 Dec 14. PMID 33327573, Free PMC Article
    2. COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. Frappaolo A, et al. J Cell Sci, 2017 Nov 1. PMID 28883096, Free PMC Article
    3. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith RD, et al. Carbohydr Res, 2008 Aug 11. PMID 18353293, Free PMC Article
    4. Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis. Belloni G, et al. J Cell Sci, 2012 Nov 15. PMID 22946051, Free PMC Article
    5. Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster. Sechi S, et al. Open Biol, 2017 Jan. PMID 28100664, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It has been demonstrated that the COG complex cooperates with Rab1 and GOLPH3 to regulate Golgi trafficking, and that overexpression of Rab1 can rescue the cytokinesis and locomotor defects associated with loss of Cog7.
      Title: COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes.
    2. Cog7 is an upstream component in a gio-Rab11 pathway controlling membrane addition during cytokinesis.
      Title: Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acroblast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    component of oligomeric golgi complex 7
    Names
    CG31040-PA
    Cog7-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29930551..29933057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143493.3 → NP_651750.1  component of oligomeric golgi complex 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZV9, Q9VAD6
      Related
      FBpp0084875
      Conserved Domains (1) summary
      pfam10191
      Location:2 → 737
      COG7; Golgi complex component 7 (COG7)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAD6.2 Q9VAD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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