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    SF2 Splicing factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SF2provided by FlyBase
    Official Full Name
    Splicing factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0283477
    Locus tag
    Dmel_CG6987
    See related
    AllianceGenome:FB:FBgn0283477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154911_at; ASF; ASF/SF2; cg6987; CG6987; dASF; Dmel\CG6987; dmSF2/p28; dSF2; dSF2/ASF; dSRp30; Sf2; SRp30; SRSF1
    Summary
    Enables DNA binding activity and mRNA binding activity. Involved in RNA export from nucleus and regulation of RNA metabolic process. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities. Orthologous to several human genes including SRSF1 (serine and arginine rich splicing factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See SF2 in Genome Data Viewer
    Location:
    89B13-89B13; 3-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16338943..16341988, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12164665..12167710, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sulfated Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene poils au dos Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mesencephalic astrocyte-derived neurotrophic factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo. Dubatolova TD, et al. Cell Biol Int, 2013 Feb. PMID 23319380
    2. SRSF1 haploinsufficiency is responsible for a syndromic developmental disorder associated with intellectual disability. Bogaert E, et al. Am J Hum Genet, 2023 May 4. PMID 37071997, Free PMC Article
    3. SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Castelli LM, et al. Mol Neurodegener, 2021 Aug 10. PMID 34376242, Free PMC Article
    4. TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1. Krupp S, et al. PLoS Genet, 2023 Sep. PMID 37747929, Free PMC Article
    5. Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Lin S, et al. Mol Cell, 2005 Nov 11. PMID 16285923

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
      Title: TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
    2. The splicing factors proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila.
      Title: The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila.
    3. Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo
      Title: Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo.
    4. The SR proteins dASF/SF2 and B52 caused defects in ommatidia structure, and B52 impaired normal axonal projections of photoreceptors and neurogenesis in visual ganglia.
      Title: The SR family proteins B52 and dASF/SF2 modulate development of the Drosophila visual system by regulating specific RNA targets.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    splicing factor 2
    Names
    CG6987-PA
    CG6987-PB
    SF2-PA
    SF2-PB
    SRp30

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16338943..16341988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260210.2 → NP_001247139.1  splicing factor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3W7
      Conserved Domains (2) summary
      cd12601
      Location:115 → 188
      RRM2_SRSF1_like; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins
      cl17169
      Location:3 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_144354.3 → NP_652611.1  splicing factor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3W7
      Related
      FBpp0082724
      Conserved Domains (2) summary
      cd12601
      Location:115 → 188
      RRM2_SRSF1_like; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins
      cl17169
      Location:3 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3W7 Q9V3W7

    Gene LinkOut

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