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    CG10089 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10089provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036369
    Locus tag
    Dmel_CG10089
    See related
    AllianceGenome:FB:FBgn0036369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10089
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytosol. Is expressed in organism. Orthologous to several human genes including DUSP22 (dual specificity phosphatase 22). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10089 in Genome Data Viewer
    Location:
    70B1-70B2; 3-40 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13465552..13474787, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13458652..13467887, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene combover Neighboring gene Jumonji domain containing 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene starvin Neighboring gene Actin binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila primary microRNA-8 encodes a microRNA-encoded peptide acting in parallel of miR-8. Montigny A, et al. Genome Biol, 2021 Apr 23. PMID 33892772, Free PMC Article
    2. The gang of four gene regulates growth and patterning of the developing Drosophila eye. Beam CK, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473027, Free PMC Article
    3. Genome-Wide Association Analysis of Anoxia Tolerance in Drosophila melanogaster. Campbell JB, et al. G3 (Bethesda), 2019 Sep 4. PMID 31311780, Free PMC Article
    4. Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc. Fan WM, et al. Insect Sci, 2021 Feb. PMID 32037698
    5. A Drosophila-centric view of protein tyrosine phosphatases. Hatzihristidis T, et al. FEBS Lett, 2015 Apr 13. PMID 25771859

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10089-PA
    CG10089-PB
    CG10089-PC
    CG10089-PD
    CG10089-PE
    CG10089-PF
    MKP-like
    NP_001261803.1
    NP_001287061.1
    NP_648654.1
    NP_729907.1
    NP_729908.1
    NP_729909.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13465552..13474787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274874.2 → NP_001261803.1  uncharacterized protein Dmel_CG10089, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI51
      Conserved Domains (1) summary
      cd00127
      Location:4 → 139
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    2. NM_001300132.1 → NP_001287061.1  uncharacterized protein Dmel_CG10089, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU80
      Conserved Domains (1) summary
      cd00127
      Location:4 → 139
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    3. NM_140397.2 → NP_648654.1  uncharacterized protein Dmel_CG10089, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU80
      Related
      FBpp0075562
      Conserved Domains (1) summary
      cd00127
      Location:4 → 139
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    4. NM_168549.3 → NP_729908.1  uncharacterized protein Dmel_CG10089, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQK1
      Related
      FBpp0075563
      Conserved Domains (1) summary
      cd00127
      Location:4 → 139
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    5. NM_168548.3 → NP_729907.1  uncharacterized protein Dmel_CG10089, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQK1
      Related
      FBpp0075564
      Conserved Domains (1) summary
      cd00127
      Location:4 → 139
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    6. NM_168550.2 → NP_729909.1  uncharacterized protein Dmel_CG10089, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQK0
      Related
      FBpp0075565
      Conserved Domains (1) summary
      cd00127
      Location:4 → 139
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI51 M9PI51
    Q8IQK0 Q8IQK0
    Q8IQK1 Q8IQK1
    Q9VU80 Q9VU80

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