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    Hf Helical Factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hfprovided by FlyBase
    Official Full Name
    Helical Factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014000
    Locus tag
    Dmel_CG10658
    See related
    AllianceGenome:FB:FBgn0014000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10658; dhf; DHF; Dmel\CG10658; GH21; Os9
    Summary
    Involved in innate immune response. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    38A8-38A8; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19966727..19967685, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19966727..19967685, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45701 Neighboring gene uncharacterized protein Neighboring gene Olfactory-specific 9 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43620 Neighboring gene long non-coding RNA:CR44908

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Helical factor is an inducible protein acting as an immune-regulated cytokine in S2 cells. Malagoli D, et al. Cytokine, 2012 May. PMID 22386007
    2. unpaired (upd)-3 expression and other immune-related functions are stimulated by interleukin-8 in Drosophila melanogaster SL2 cell line. Malagoli D, et al. Cytokine, 2008 Nov. PMID 18926718
    3. A putative helical cytokine functioning in innate immune signalling in Drosophila melanogaster. Malagoli D, et al. Biochim Biophys Acta, 2007 Jun. PMID 17399906
    4. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Cannavò E, et al. Nature, 2017 Jan 19. PMID 28024300
    5. Multiple Niche Compartments Orchestrate Stepwise Germline Stem Cell Progeny Differentiation. Tu R, et al. Curr Biol, 2021 Feb 22. PMID 33357404, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila helical factor (dhf) expression is under control of the immune deficiency (Imd) pathway.
      Title: unpaired (upd)-3 expression and other immune-related functions are stimulated by interleukin-8 in Drosophila melanogaster SL2 cell line.
    2. The Drosophila Helical Factor (DHF) protein has a possible role in innate immunity.
      Title: A putative helical cytokine functioning in innate immune signalling in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in innate immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    helical factor
    Names
    CG10658-PA
    Hf-PA
    Olfactory-specific 9
    drosophila helical factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19966727..19967685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176064.3 → NP_788078.1  helical factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788078.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIQ4
      Related
      FBpp0080841
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIQ4 Q9VIQ4

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