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    DNAlig3 DNA ligase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41518, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DNAlig3provided by FlyBase
    Official Full Name
    DNA ligase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0286075
    Locus tag
    Dmel_CG17227
    See related
    AllianceGenome:FB:FBgn0286075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17227; Dmel\CG17227; DNA-ligII; lig 3; lig3; Lig3; LIG3
    Summary
    Predicted to enable DNA ligase (ATP) activity. Predicted to be involved in base-excision repair, DNA ligation; double-strand break repair; and lagging strand elongation. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 20 and pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DNAlig3 in Genome Data Viewer
    Location:
    87B9-87B9; 3-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12399011..12401839, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8224733..8227561, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sol1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 9f3 Neighboring gene Cytochrome P450 9f2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of DNA ligase II from Drosophila melanogaster. Takahashi M, et al. Eur J Biochem, 1990 Sep 24. PMID 2120058
    2. Eukaryotic DNA ligases. Lasko DD, et al. Mutat Res, 1990 Sep-Nov. PMID 2204827
    3. Two distinct DNA ligases from Drosophila melanogaster embryos. Takahashi M, et al. FEBS Lett, 1987 Mar 23. PMID 3104089
    4. Distribution of DNA replication proteins in Drosophila cells. Easwaran HP, et al. BMC Cell Biol, 2007 Oct 15. PMID 17937809, Free PMC Article
    5. DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens. Mota MBS, et al. Parasit Vectors, 2019 Nov 11. PMID 31711518, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, DNA ligation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA ligase 3
    Names
    CG17227-PA
    DNA ligase II
    DNA ligase III
    DNAlig3-PA
    ligase III
    NP_650187.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12399011..12401839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141930.3 → NP_650187.2  DNA ligase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650187.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZC0, Q9VG84
      Conserved Domains (4) summary
      cd07967
      Location:460 → 598
      OBF_DNA_ligase_III; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase III is a DNA-binding module that is part of the catalytic core unit
      cd07902
      Location:242 → 454
      Adenylation_DNA_ligase_III; Adenylation domain of DNA Ligase III
      TIGR00574
      Location:88 → 604
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam04675
      Location:36 → 200
      DNA_ligase_A_N; DNA ligase N terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZC0 Q8MZC0
    Q9VG84 Q9VG84

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