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    hig hikaru genki [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    higprovided by FlyBase
    Official Full Name
    hikaru genkiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010114
    Locus tag
    Dmel_CG2040
    See related
    AllianceGenome:FB:FBgn0010114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2040; CT6282; Dmel\CG2040; Hig; HIG
    Summary
    Involved in synaptic target recognition. Located in neuronal cell body and synaptic cleft. Is expressed in several structures, including adult brain; central brain primordium; embryonic central brain neurons; ganglia; and head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hig in Genome Data Viewer
    Location:
    45B7-45B8; 2-60 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9227785..9247249, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5115290..5134754, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45309 Neighboring gene long non-coding RNA:CR44451 Neighboring gene Cytochrome P450 4p2 Neighboring gene Cytochrome P450 4p1 Neighboring gene Cytochrome P450 4p3 Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene Protein kinase N Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila. Hoshino M, et al. Development, 1996 Feb. PMID 8625810
    2. Neural expression of hikaru genki protein during embryonic and larval development of Drosophila melanogaster. Hoshino M, et al. Dev Genes Evol, 1999 Jan. PMID 9914413
    3. hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein. Hoshino M, et al. Neuron, 1993 Mar. PMID 8461133
    4. Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. Sone M, et al. PLoS One, 2009. PMID 19209226, Free PMC Article
    5. The matrix protein Hikaru genki localizes to cholinergic synaptic clefts and regulates postsynaptic organization in the Drosophila brain. Nakayama M, et al. J Neurosci, 2014 Oct 15. PMID 25319684, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dalpha5 and Secreted Scaffold Protein Hig.
      Title: Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dα5 and Secreted Scaffold Protein Hig.
    2. These data provide insight into how Hasp and Hig construct the synaptic cleft matrix and regulate the differentiation of cholinergic synapses, and also illuminate a previously unidentified architecture within synaptic clefts
      Title: The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis.
    3. Hig is a specific component of the synaptic cleft matrix of cholinergic synapses and regulates their postsynaptic organization.
      Title: The matrix protein Hikaru genki localizes to cholinergic synaptic clefts and regulates postsynaptic organization in the Drosophila brain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c9237124-9237044 mobile_element_type = transposon:INE-1{}3581

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hikaru genki
    Names
    CG2040-PA
    CG2040-PB
    CG2040-PC
    CG2040-PD
    hig-PA
    hig-PB
    hig-PC
    hig-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9227785..9247249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165666.2 → NP_724772.1  hikaru genki, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R955
      Related
      FBpp0087687
      Conserved Domains (3) summary
      cd00033
      Location:807 → 866
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:680 → 927
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:869 → 927
      Sushi; Sushi repeat (SCR repeat)

    2. NM_080371.3 → NP_525110.2  hikaru genki, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525110.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R955
      Related
      FBpp0087689
      Conserved Domains (1) summary
      cd00033
      Location:807 → 866
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    3. NM_165667.2 → NP_724773.1  hikaru genki, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09101, Q7KQU0, Q8IH50, Q9I7E3, Q9I7E4, Q9V560
      UniProtKB/TrEMBL
      E0R955
      Related
      FBpp0087688
      Conserved Domains (3) summary
      cd00033
      Location:832 → 891
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:705 → 952
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:894 → 952
      Sushi; Sushi repeat (SCR repeat)

    4. NM_001014514.2 → NP_001014514.1  hikaru genki, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014514.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R955
      Conserved Domains (1) summary
      cd00033
      Location:832 → 891
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09101.2 Q09101

    Gene LinkOut

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