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    CycY Cyclin Y [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CycYprovided by FlyBase
    Official Full Name
    Cyclin Yprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032378
    Locus tag
    Dmel_CG14939
    See related
    AllianceGenome:FB:FBgn0032378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.165; CG14939; Dcyclin Y; Dmel\CG14939; i182
    Summary
    Enables cyclin-dependent protein serine/threonine kinase activator activity. Involved in developmental growth and positive regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head and organism. Orthologous to several human genes including CCNY (cyclin Y). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CycY in Genome Data Viewer
    Location:
    33A2-33A2; 2-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11810092..11813780, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11810092..11813780, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene crooked legs Neighboring gene Phosphodiesterase 1c Neighboring gene uncharacterized protein Neighboring gene extra sexcombs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Liu D, et al. Genetics, 2010 Apr. PMID 20100936, Free PMC Article
    2. Cell cycle control of wnt receptor activation. Davidson G, et al. Dev Cell, 2009 Dec. PMID 20059949
    3. Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster. Szlanka T, et al. G3 (Bethesda), 2024 Sep 4. PMID 38985658, Free PMC Article
    4. Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP. Battersby A, et al. J Mol Biol, 2003 Jun 6. PMID 12767830
    5. Genome-wide identification of phospho-regulators of Wnt signaling in Drosophila. Swarup S, et al. Development, 2015 Apr 15. PMID 25852200

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CycY/Eip63E form a cyclin/Cdk complex that is essential for several developmental processes.
      Title: Cyclin Y is a novel conserved cyclin essential for development in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin Y
    Names
    CG14939-PA
    CG14939-PB
    CycY-PA
    CycY-PB
    drosophila cyclin Y

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11810092..11813780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273465.1 → NP_001260394.1  cyclin Y, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKF0
      Conserved Domains (1) summary
      pfam00134
      Location:205 → 327
      Cyclin_N; Cyclin, N-terminal domain

    2. NM_135675.4 → NP_609519.1  cyclin Y, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKF0
      Related
      FBpp0079843
      Conserved Domains (1) summary
      pfam00134
      Location:205 → 327
      Cyclin_N; Cyclin, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKF0 Q9VKF0

    Gene LinkOut

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