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    Gart GART trifunctional enzyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gartprovided by FlyBase
    Official Full Name
    GART trifunctional enzymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000053
    Locus tag
    Dmel_CG31628
    See related
    AllianceGenome:FB:FBgn0000053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143062_at; ade3; Ade3; ADE8; CG31628; CG8761; D; Dmel\CG31628; gart; GART; Gart/ade3; l(2)27Da
    Summary
    Enables phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; and phosphoribosylglycinamide formyltransferase activity. Involved in purine nucleobase biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; embryonic/larval midgut primordium; and gut section. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gart in Genome Data Viewer
    Location:
    27D4-27D4; 2-24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7014623..7023898, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7014623..7023898, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uninflatable Neighboring gene long non-coding RNA:CR44326 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Pupal cuticle protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial Magnesium Exporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Origin of genes encoding multi-enzymatic proteins in eukaryotes. Davidson JN, et al. Trends Genet, 1997 Jul. PMID 9242051
    2. A Drosophila metabolic gene transcript is alternatively processed. Henikoff S, et al. Cell, 1983 Sep. PMID 6413075
    3. Isolation of a gene from Drosophila by complementation in yeast. Henikoff S, et al. Nature, 1981 Jan 1. PMID 6256646
    4. Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila. Henikoff S, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3080748, Free PMC Article
    5. Cloning exons of mapping of transcription: characterization of the Drosophila melanogaster alcohol dehydrogenase gene. Henikoff S. Nucleic Acids Res, 1983 Jul 25. PMID 6410356, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila.
      Title: Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylamine-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoribosylglycinamide formyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylglycinamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylglycinamide formyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleobase biosynthetic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GART trifunctional enzyme
    Names
    CG31628-PA
    CG31628-PB
    CG31628-PC
    Gart-PA
    Gart-PB
    Gart-PC
    adenosine 3
    complementation group D
    NP_001014477.1
    NP_001285698.1
    NP_523497.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7014623..7023898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298769.1 → NP_001285698.1  GART trifunctional enzyme, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDH3, X2J516
      Conserved Domains (7) summary
      cd02196
      Location:840 → 1123
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:1155 → 1339
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4 → 433
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:442 → 752
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      pfam01071
      Location:108 → 301
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:337 → 430
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 107
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    2. NM_078773.3 → NP_523497.2  GART trifunctional enzyme, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523497.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDH3, X2J516
      Related
      FBpp0079059
      Conserved Domains (7) summary
      cd02196
      Location:840 → 1123
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:1155 → 1339
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4 → 433
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:442 → 752
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      pfam01071
      Location:108 → 301
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:337 → 430
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 107
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    3. NM_001014477.2 → NP_001014477.1  GART trifunctional enzyme, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DZ6
      Conserved Domains (4) summary
      PRK00885
      Location:4 → 433
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      pfam01071
      Location:108 → 301
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:337 → 430
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 107
      GARS_N; Phosphoribosylglycinamide synthetase, N domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00967.2 P00967
    Q59DZ6 Q59DZ6
    X2J516 X2J516

    Gene LinkOut

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