spdo sanpodo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: spdoprovided by FlyBase
Official Full Name: sanpodoprovided by FlyBase
Primary source: FLYBASE:FBgn0260440
Locus tag: Dmel_CG31020
See related: AllianceGenome:FB:FBgn0260440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0970/02; BcDNA:RE23355; CG31020; Dmel\CG31020; Spdo
Old locus tag: CG31020
Summary: Enables Notch binding activity. Involved in heart morphogenesis; regulation of Notch signaling pathway; and sensory organ precursor cell division. Located in several cellular components, including cortical cytoskeleton; cytosol; and endosome. Colocalizes with cytoplasmic vesicle. Is expressed in several structures, including larval central nervous system; larval peripheral nervous system; presumptive embryonic/larval system; somatic precursor cell; and unpaired neurons. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99F6-99F6; 3-100 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30476684..30478849)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26302406..26304571)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Strat is required to localize Rab8 at the TGN, and rab8 phenocopies strat We propose that Strat and Rab8 act at the exit of the Golgi apparatus to regulate the sorting and the polarized distribution of Notch, Delta and Spdo.
Title: Stratum recruits Rab8 at Golgi exit sites to regulate the basolateral sorting of Notch and Sanpodo.
Spdo is sorted toward late endosomes in a Numb-dependent manner.
Title: A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo.
In numb mutant cells, internalized Spdo localizes at the basolateral interface of the pIIa/pIIb cells.
Title: Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor.
Sanpodo suppresses Notch signaling by driving Notch receptor internalization.
Title: Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase.
It was shown that the AP-1 complex causes apical accumulation of the Notch activator Sanpodo and stabilization of both Sanpodo and Notch at the interface between sense organ precursor daughter cells.
Title: AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors.
Sanpodo contains an evolutionarily conserved motif that has been linked to Numb-dependent regulation in vertebrates; Numb regulates Notch signaling independently of Sanpodo membrane trafficking in neural progenitor cells
Title: Numb independently antagonizes Sanpodo membrane targeting and Notch signaling in Drosophila sensory organ precursor cells.
the restricted ability of Sanpodo to promote Notch signaling during asymmetric divisions
Title: Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions.
numb- and alpha-adaptin-dependent endocytosis of Sanpodo is the mechanism by which Notch is regulated during external sensory organ development.
Title: Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed