ry rosy [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ryprovided by FlyBase
Official Full Name: rosyprovided by FlyBase
Primary source: FLYBASE:FBgn0003308
Locus tag: Dmel_CG7642
See related: AllianceGenome:FB:FBgn0003308
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7642; Dmel\CG7642; Ry; xdh; Xdh; XDH; Xdh/ry; XOR
Summary: Enables xanthine dehydrogenase activity. Involved in several processes, including alpha-amino acid metabolic process; determination of adult lifespan; and nucleobase metabolic process. Is expressed in several structures, including adult head; antennal anlage; endoderm anlage; germline cell; and gut section. Used to study xanthinuria. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; cardiovascular system disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria type I. Orthologous to several human genes including XDH (xanthine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13032528..13038020)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8858250..8863742)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Xdh appears to be fixing more A/T mutations than G/C mutations in most lineages, leading to evolution of higher A/T content in the recent past.
Title: Molecular population genetics of Xdh and the evolution of base composition in Drosophila.
expression in Aspergillus nidulans and properties
Title: Expression of Drosophila melanogaster xanthine dehydrogenase in Aspergillus nidulans and some properties of the recombinant enzyme.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	ISS Inferred from Sequence or Structural Similarity more info
enables xanthine dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables xanthine dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables xanthine dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xanthine dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in arginine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerophospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine nucleobase metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine nucleobase metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tryptophan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xanthine catabolic process	ISS Inferred from Sequence or Structural Similarity more info

NP_524337.1

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The following sections contain reference sequences that belong to a specific genome build. Explain