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    CG42366 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42366provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259712
    Locus tag
    Dmel_CG42366
    See related
    AllianceGenome:FB:FBgn0259712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31711; CG31878; CG4588; Dmel\CG42366; IME2; MAK
    Old locus tag
    Dmel_CG31711; Dmel_CG31878
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cilium assembly; intracellular signal transduction; and intraciliary transport. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome; juvenile myoclonic epilepsy 10; and retinitis pigmentosa 62. Orthologous to several human genes including MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42366 in Genome Data Viewer
    Location:
    30F1-30F1; 2-38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9925161..9930378)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9925161..9930378)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TbCMF46 Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 30F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive gene amplification and concerted evolution within the CPR family of cuticular proteins in mosquitoes. Cornman RS, et al. Insect Biochem Mol Biol, 2008 Jun. PMID 18510978, Free PMC Article
    2. Protein kinases and phosphatases in the Drosophila genome. Morrison DK, et al. J Cell Biol, 2000 Jul 24. PMID 10908587, Free PMC Article
    3. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
    4. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. Pogson JH, et al. PLoS Genet, 2014 Nov. PMID 25412178, Free PMC Article
    5. Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila. Haerty W, et al. Genetics, 2007 Nov. PMID 18039869, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42366-PA
    CG42366-PB
    NP_001260307.1
    NP_723501.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9925161..9930378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164876.4 → NP_723501.2  uncharacterized protein Dmel_CG42366, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723501.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3H0, Q9VL64
      Conserved Domains (2) summary
      smart00220
      Location:4 → 284
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    2. NM_001273378.1 → NP_001260307.1  uncharacterized protein Dmel_CG42366, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3H0, M9PFE3
      Conserved Domains (2) summary
      smart00220
      Location:4 → 284
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFE3 M9PFE3
    Q9VL64 Q9VL64

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