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    Pdk Pyruvate dehydrogenase kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35970, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pdkprovided by FlyBase
    Official Full Name
    Pyruvate dehydrogenase kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017558
    Locus tag
    Dmel_CG8808
    See related
    AllianceGenome:FB:FBgn0017558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD09837; CG8808; Dmel\CG8808; DmPdk; DmPDK; PDHK; pdk; PDK
    Summary
    Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in regulation of acetyl-CoA biosynthetic process from pyruvate and regulation of glucose metabolic process. Predicted to be part of pyruvate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to several human genes including PDK1 (pyruvate dehydrogenase kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pdk in Genome Data Viewer
    Location:
    45D5-45D7; 2-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9426439..9434638)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5313944..5322143)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene preli-like Neighboring gene ced-6 Neighboring gene long non-coding RNA:CR45321

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA sequence and expression of a gene encoding a pyruvate dehydrogenase kinase homolog of Drosophila melanogaster. Katsube T, et al. DNA Cell Biol, 1997 Mar. PMID 9115642
    2. Pyruvate Dehydrogenase Kinase Protects Dopaminergic Neurons from Oxidative Stress in Drosophila DJ-1 Null Mutants. Lee Y, et al. Mol Cells, 2022 Jul 31. PMID 35444068, Free PMC Article
    3. Mitochondrial dysfunction generates a growth-restraining signal linked to pyruvate in Drosophila larvae. George J, et al. Fly (Austin), 2019 Mar-Dec. PMID 31526131, Free PMC Article
    4. CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases. Lambrechts RA, et al. EMBO Mol Med, 2019 Dec. PMID 31701655, Free PMC Article
    5. Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory. Plaçais PY, et al. Nat Commun, 2017 Jun 5. PMID 28580949, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pyruvate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase kinase
    Names
    CG8808-PA
    CG8808-PB
    CG8808-PC
    CG8808-PD
    Pdk-PA
    Pdk-PB
    Pdk-PC
    Pdk-PD
    NP_001097240.1
    NP_001246224.1
    NP_001260825.1
    NP_477215.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9426439..9434638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273896.1 → NP_001260825.1  pyruvate dehydrogenase kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260825.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFG2
      Conserved Domains (2) summary
      cd16929
      Location:197 → 366
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
      pfam10436
      Location:32 → 193
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    2. NM_001103770.2 → NP_001097240.1  pyruvate dehydrogenase kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY78
      Conserved Domains (2) summary
      cd16929
      Location:197 → 366
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
      pfam10436
      Location:32 → 193
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    3. NM_001259295.2 → NP_001246224.1  pyruvate dehydrogenase kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91622, Q9V580
      UniProtKB/TrEMBL
      A0A0B4K7V5
      Conserved Domains (3) summary
      smart00387
      Location:244 → 366
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:197 → 374
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:32 → 193
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    4. NM_057867.4 → NP_477215.1  pyruvate dehydrogenase kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91622, Q9V580
      UniProtKB/TrEMBL
      A0A0B4K7V5
      Related
      FBpp0087592
      Conserved Domains (3) summary
      smart00387
      Location:244 → 366
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:197 → 374
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:32 → 193
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7V5 A0A0B4K7V5
    A0A0B4KFG2 A0A0B4KFG2
    A8DY78 A8DY78
    P91622.2 P91622

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