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    Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85243, updated on 9-Dec-2024

    Summary

    Symbol
    Pik3cbprovided by RGD
    Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaprovided by RGD
    Primary source
    RGD:620917
    See related
    EnsemblRapid:ENSRNOG00000016384 AllianceGenome:RGD:620917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in brush border membrane. Part of phosphatidylinositol 3-kinase complex. Used to study thrombosis. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 103.9), Lung (RPKM 81.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pik3cb in Genome Data Viewer
    Location:
    8q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108474017..108579140, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99594600..99699772, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107275849..107381088, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene forkhead box L2 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene coxsackie virus and adenovirus receptor-like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134479984

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis involved in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within angiogenesis involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic cleavage IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic cleavage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Rac protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphatidylinositol 3-kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Names
    PI3-kinase p110 subunit beta
    PI3-kinase subunit beta
    PI3K
    PI3K-beta
    PI3Kbeta
    catalytic phosphatidylinositol 3-kinase beta
    p110beta
    phosphatidylinositol 3-kinase, catalytic, beta polypeptide
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
    phosphoinositide-3-kinase, catalytic, beta polypeptide
    ptdIns-3-kinase p110
    ptdIns-3-kinase subunit beta
    ptdIns-3-kinase subunit p110-beta
    serine/threonine protein kinase PIK3CB
    NP_445933.1
    XP_017451432.1
    XP_017451435.1
    XP_017451436.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053481.2NP_445933.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      See identical proteins and their annotated locations for NP_445933.1

      Status: VALIDATED

      Source sequence(s)
      AJ012482, AW523465, BQ202622, CV117575, EV762942, EV765206
      UniProtKB/Swiss-Prot
      Q9Z1L0
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      108474017..108579140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595943.3XP_017451432.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A6I2C5, G3V839
      Related
      ENSRNOP00000111949.1, ENSRNOT00000154056.1
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    2. XM_017595946.3XP_017451435.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A6I2C5, G3V839
      Related
      ENSRNOP00000022179.3, ENSRNOT00000022179.6
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    3. XM_017595947.3XP_017451436.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A6I2C5, G3V839
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    RNA

    1. XR_005487938.2 RNA Sequence

    2. XR_010054039.1 RNA Sequence