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    Trhr thyrotropin releasing hormone receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25570, updated on 3-Dec-2024

    Summary

    Official Symbol
    Trhrprovided by RGD
    Official Full Name
    thyrotropin releasing hormone receptorprovided by RGD
    Primary source
    RGD:3904
    See related
    EnsemblRapid:ENSRNOG00000005048 AllianceGenome:RGD:3904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity and thyrotropin-releasing hormone receptor activity. Involved in positive regulation of cytosolic calcium ion concentration and positive regulation of protein-containing complex assembly. Located in cell surface. Used to study hypertension. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 16.6), Thymus (RPKM 13.9) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Trhr in Genome Data Viewer
    Location:
    7q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (77233175..77277988)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (75348672..75393310)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (83113641..83153520)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479720 Neighboring gene eukaryotic translation initiation factor 3 subunit E, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene NudC domain containing 1 Neighboring gene ENY2, transcription and export complex 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    thyrotropin-releasing hormone receptor
    Names
    TRH-R
    thyroliberin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013047.3NP_037179.1  thyrotropin-releasing hormone receptor

      See identical proteins and their annotated locations for NP_037179.1

      Status: VALIDATED

      Source sequence(s)
      AW522207, M90308, X66726
      UniProtKB/Swiss-Prot
      Q01717, Q63948, Q63949
      UniProtKB/TrEMBL
      A6HRA7, G3V6M9
      Related
      ENSRNOP00000006783.4, ENSRNOT00000006783.7
      Conserved Domains (2) summary
      pfam00001
      Location:42320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:38194
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      77233175..77277988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263031.1XP_063119101.1  thyrotropin-releasing hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6HRA7, G3V6M9