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    Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25578, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ywhazprovided by RGD
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zetaprovided by RGD
    Primary source
    RGD:3980
    See related
    EnsemblRapid:ENSRNOG00000008195 AllianceGenome:RGD:3980
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    14-3-3z
    Summary
    Predicted to enable several functions, including enzyme binding activity; protein sequestering activity; and transmembrane transporter binding activity. Involved in histamine secretion by mast cell; protein targeting to mitochondrion; and response to xenobiotic stimulus. Located in cell leading edge and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in postsynaptic specialization. Biomarker of childhood absence epilepsy; hypertension; and visual epilepsy. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 1746.4), Adrenal (RPKM 1156.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ywhaz in Genome Data Viewer
    Location:
    7q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (69826404..69848702, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (67941353..67963651, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (75573553..75598295, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 1 Neighboring gene uncharacterized LOC134479712 Neighboring gene uncharacterized LOC100910524 Neighboring gene zinc finger protein 706 Neighboring gene uncharacterized LOC134479896

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoserine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoserine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoserine residue binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein sequestering activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi reassembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi reassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of Golgi localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synapse maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic target recognition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic target recognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic specialization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    14-3-3 protein zeta/delta
    Names
    KCIP-1
    mitochondrial import stimulation factor S1 subunit
    protein kinase C inhibitor protein 1
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013011.4NP_037143.2  14-3-3 protein zeta/delta

      See identical proteins and their annotated locations for NP_037143.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P63102, Q52KK1, Q6IRF4
      UniProtKB/TrEMBL
      A0A0G2JV65, A6HR34
      Related
      ENSRNOP00000082109.1, ENSRNOT00000096774.2
      Conserved Domains (1) summary
      cd10022
      Location:2230
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      69826404..69848702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)