U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cdr2 cerebellar degeneration-related 2 [ Mus musculus (house mouse) ]

    Gene ID: 12585, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cdr2provided by MGI
    Official Full Name
    cerebellar degeneration-related 2provided by MGI
    Primary source
    MGI:MGI:1100885
    See related
    Ensembl:ENSMUSG00000030878 AllianceGenome:MGI:1100885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Located in cytoplasm. Is expressed in central nervous system; liver lobe; and retina. Orthologous to human CDR2 (cerebellar degeneration related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 62.2), liver E14.5 (RPKM 61.4) and 25 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cdr2 in Genome Data Viewer
    Location:
    7 F2; 7 65.04 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120556259..120581535, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120957036..120982312, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2845 Neighboring gene STARR-positive B cell enhancer ABC_E6593 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene polymerase (RNA) III (DNA directed) polypeptide E Neighboring gene STARR-positive B cell enhancer ABC_E450 Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene predicted pseudogene 9234 Neighboring gene predicted gene, 25924

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A post-transcriptional regulatory mechanism restricts expression of the paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged tissues. Corradi JP, et al. J Neurosci, 1997 Feb 15. PMID 9006982, Free PMC Article
    2. T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy. Blachère NE, et al. JCI Insight, 2017 Nov 2. PMID 29093272, Free PMC Article
    3. The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. Okano HJ, et al. Genes Dev, 1999 Aug 15. PMID 10465786, Free PMC Article
    4. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
    5. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. Fletcher CF, et al. Genomics, 1997 Oct 15. PMID 9344654

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC144810, MGC144811

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cerebellar degeneration-related protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354986.1 → NP_001341915.1  cerebellar degeneration-related protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122248

    2. NM_007672.2 → NP_031698.2  cerebellar degeneration-related protein 2 isoform 1

      See identical proteins and their annotated locations for NP_031698.2

      Status: VALIDATED

      Source sequence(s)
      BC117530, BX637405, BY713743, CF616011, DT902919
      Consensus CDS
      CCDS21798.1
      UniProtKB/Swiss-Prot
      P97817, Q3UG92
      UniProtKB/TrEMBL
      Q3TAP7
      Related
      ENSMUSP00000033169.9, ENSMUST00000033169.9
      Conserved Domains (1) summary
      TIGR02168
      Location:19 → 262
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120556259..120581535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97817.2 GenPept UniProtKB/Swiss-Prot:P97817

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools