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    Adam19 ADAM metallopeptidase domain 19 [ Mus musculus (house mouse) ]

    Gene ID: 11492, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adam19provided by MGI
    Official Full Name
    ADAM metallopeptidase domain 19provided by MGI
    Primary source
    MGI:MGI:105377
    See related
    Ensembl:ENSMUSG00000011256 AllianceGenome:MGI:105377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTLNB; Mltnb; MADDAM
    Summary
    This gene encodes a cell surface glycoprotein and member of the ADAM (a disintegrin and metalloproteinase) family of endopeptidases. The encoded protein may play a role in the ectodomain shedding of neuregulin proteins. Homozygous knockout mice for this gene exhibit heart development defects and perinatal lethality. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that undergoes proteolytic processing to generate a mature protein product. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in lung adult (RPKM 11.0), limb E14.5 (RPKM 10.3) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adam19 in Genome Data Viewer
    Location:
    11 B1.1; 11 27.54 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (45945329..46038174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46054502..46147347)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29310 Neighboring gene predicted gene 12165 Neighboring gene STARR-positive B cell enhancer ABC_E10671 Neighboring gene SFT2 domain containing 1, retrotransposed Neighboring gene STARR-seq mESC enhancer starr_29320 Neighboring gene microRNA 8100 Neighboring gene STARR-seq mESC enhancer starr_29321 Neighboring gene STARR-positive B cell enhancer ABC_E3942 Neighboring gene STARR-positive B cell enhancer ABC_E8393 Neighboring gene STARR-positive B cell enhancer ABC_E5219 Neighboring gene NIPA-like domain containing 4 Neighboring gene predicted gene, 35624 Neighboring gene microRNA 7239

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding PubMed 
    enables metal ion binding  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in collagen-containing extracellular matrix PubMed 
    NOT located_in external side of plasma membrane PubMed 
    located_in membrane  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 19
    Names
    MDC beta
    Mel beta
    a disintegrin and metallopeptidase domain 19 (meltrin beta)
    a disintegrin and metalloproteinase domain 19 (meltrin beta)
    adamalysin 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291890.1NP_001278819.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 2

      See identical proteins and their annotated locations for NP_001278819.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK147549, BC093480, CJ248266
      UniProtKB/TrEMBL
      Q3UH67
      Conserved Domains (5) summary
      smart00050
      Location:420480
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:482630
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:191387
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:191389
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:35142
      Pep_M12B_propep; Reprolysin family propeptide
    2. NM_001291891.1NP_001278820.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate internal splice site, compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL663031, BC093480, CJ248266
      Conserved Domains (3) summary
      smart00050
      Location:123183
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:185333
      ACR; ADAM Cysteine-Rich Domain
      cl00064
      Location:390
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    3. NM_001311209.1NP_001298138.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as meltrin beta mini) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus and lacks the prodomain, metalloprotease and disintegrin domains, compared to isoform 1.
      Source sequence(s)
      AK147217, AL663031, CJ248266
      UniProtKB/TrEMBL
      Q80UF6
      Conserved Domains (1) summary
      smart00608
      Location:1149
      ACR; ADAM Cysteine-Rich Domain
    4. NM_009616.4NP_033746.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_033746.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK147217, AL663031, CJ111383, CJ248266
      Consensus CDS
      CCDS24571.1
      UniProtKB/Swiss-Prot
      O35674
      UniProtKB/TrEMBL
      Q3UHT3
      Related
      ENSMUSP00000011400.8, ENSMUST00000011400.8
      Conserved Domains (5) summary
      smart00050
      Location:440500
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:502650
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211407
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:211409
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:55162
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      45945329..46038174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245480.2XP_030101340.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X2

      Conserved Domains (3) summary
      smart00050
      Location:239299
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:301449
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:10208
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    2. XM_036156242.1XP_036012135.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X1

      Conserved Domains (4) summary
      smart00050
      Location:417477
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:479627
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:188386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62140
      Pep_M12B_propep; Reprolysin family propeptide
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