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    Oprd1 opioid receptor, delta 1 [ Mus musculus (house mouse) ]

    Gene ID: 18386, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oprd1provided by MGI
    Official Full Name
    opioid receptor, delta 1provided by MGI
    Primary source
    MGI:MGI:97438
    See related
    Ensembl:ENSMUSG00000050511 AllianceGenome:MGI:97438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DOR; Nbor; mDOR; DOR-1
    Summary
    Enables G protein-coupled opioid receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adult locomotory behavior; and neuropeptide signaling pathway. Located in membrane. Is active in neuronal dense core vesicle. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and neural retina. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Orthologous to human OPRD1 (opioid receptor delta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.5), cortex adult (RPKM 2.6) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Oprd1 in Genome Data Viewer
    Location:
    4 D2.3; 4 64.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131834980..131872042, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132110188..132144486, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1 Neighboring gene VISTA enhancer mm1387 Neighboring gene STARR-positive B cell enhancer ABC_E4674 Neighboring gene predicted gene, 36157 Neighboring gene VISTA enhancer mm80 Neighboring gene STARR-positive B cell enhancer ABC_E3518 Neighboring gene STARR-seq mESC enhancer starr_11553 Neighboring gene STARR-seq mESC enhancer starr_11554 Neighboring gene nuclear encoded tRNA alanine 3 (anticodon CGC) Neighboring gene STARR-seq mESC enhancer starr_11556 Neighboring gene predicted gene 13215 Neighboring gene STARR-seq mESC enhancer starr_11557 Neighboring gene YTH N6-methyladenosine RNA binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway  
    involved_in G protein-coupled opioid receptor signaling pathway  
    involved_in G protein-coupled opioid receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    NOT acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within adult locomotory behavior PubMed 
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to hypoxia  
    involved_in cellular response to hypoxia  
    involved_in cellular response to toxic substance  
    involved_in cellular response to toxic substance  
    involved_in eating behavior  
    involved_in eating behavior  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in neuropeptide signaling pathway  
    acts_upstream_of_or_within neuropeptide signaling pathway PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in regulation of calcium ion transport  
    involved_in regulation of calcium ion transport  
    involved_in regulation of mitochondrial membrane potential  
    involved_in regulation of mitochondrial membrane potential  
    involved_in response to ethanol  
    involved_in response to nicotine  
    Items 1 - 25 of 29
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in axon terminus  
    located_in axon terminus  
    located_in dendrite membrane  
    located_in dendrite membrane  
    located_in membrane PubMed 
    is_active_in neuron projection  
    is_active_in neuronal dense core vesicle PubMed 
    is_active_in neuronal dense core vesicle PubMed 
    is_active_in neuronal dense core vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane  
    located_in postsynaptic membrane  
    located_in presynaptic membrane  
    is_active_in presynaptic membrane  
    located_in spine apparatus  
    is_active_in spine apparatus  
    located_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane  
    located_in vesicle  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    delta-type opioid receptor
    Names
    D-OR-1
    K56
    MSL-2
    delta 1 opioid receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013622.3NP_038650.3  delta-type opioid receptor

      See identical proteins and their annotated locations for NP_038650.3

      Status: VALIDATED

      Source sequence(s)
      AK043873, L06322
      Consensus CDS
      CCDS18718.1
      UniProtKB/Swiss-Prot
      P32300
      UniProtKB/TrEMBL
      A2AD37, Q8BLP9
      Related
      ENSMUSP00000050077.2, ENSMUST00000056336.2
      Conserved Domains (2) summary
      pfam00001
      Location:66318
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:59232
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131834980..131872042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538628.5XP_006538691.1  delta-type opioid receptor isoform X1

      UniProtKB/TrEMBL
      B1ACW5
      Conserved Domains (2) summary
      cd14964
      Location:3561
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:27280
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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