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    Ctdsp2 CTD small phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 52468, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctdsp2provided by MGI
    Official Full Name
    CTD small phosphatase 2provided by MGI
    Primary source
    MGI:MGI:1098748
    See related
    Ensembl:ENSMUSG00000078429 AllianceGenome:MGI:1098748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OS4; OS-4; SCP2; D10Ertd73e
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; integumental system; and respiratory system. Orthologous to human CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 75.2), limb E14.5 (RPKM 74.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ctdsp2 in Genome Data Viewer
    Location:
    10 D3; 10 74.35 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126814586..126835844)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (126978717..126999975)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30539 Neighboring gene STARR-seq mESC enhancer starr_28199 Neighboring gene STARR-positive B cell enhancer ABC_E3925 Neighboring gene predicted gene, 40798 Neighboring gene microRNA 26a-2 Neighboring gene microRNA 546 Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Clone Names

    • MGC38258

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cellular_component  
    located_in nucleus  

    General protein information

    Preferred Names
    carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
    nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4)
    small C-terminal domain phosphatase 2
    NP_001106941.1
    NP_666124.1
    XP_036011783.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113470.1NP_001106941.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform a

      See identical proteins and their annotated locations for NP_001106941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK049271, BB731474, BC085142
      Consensus CDS
      CCDS48711.1
      UniProtKB/Swiss-Prot
      Q8BX07
      Related
      ENSMUSP00000100891.3, ENSMUST00000105256.10
      Conserved Domains (1) summary
      TIGR02251
      Location:100259
      HIF-SF_euk; Dullard-like phosphatase domain
    2. NM_146012.2NP_666124.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform b

      See identical proteins and their annotated locations for NP_666124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant a. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AA103008, AK049271, BB731474, CB527995
      Consensus CDS
      CCDS36076.1
      UniProtKB/TrEMBL
      Q8R3B3
      Related
      ENSMUSP00000100890.3, ENSMUST00000105255.3
      Conserved Domains (1) summary
      cl21460
      Location:1108
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      126814586..126835844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155890.1XP_036011783.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform X1

      Conserved Domains (1) summary
      TIGR02251
      Location:87246
      HIF-SF_euk; Dullard-like phosphatase domain
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