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    Osgin2 oxidative stress induced growth inhibitor family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 209212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Osgin2provided by MGI
    Official Full Name
    oxidative stress induced growth inhibitor family member 2provided by MGI
    Primary source
    MGI:MGI:2384798
    See related
    Ensembl:ENSMUSG00000041153 AllianceGenome:MGI:2384798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230027H09Rik
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. Is expressed in cerebral cortex; ganglia; and medulla oblongata basal plate mantle layer. Orthologous to human OSGIN2 (oxidative stress induced growth inhibitor family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.0), cerebellum adult (RPKM 2.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osgin2 in Genome Data Viewer
    Location:
    4 A2; 4 6.66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (15996354..16015266, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (15996354..16015258, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene 2,4-dienoyl CoA reductase 1, mitochondrial Neighboring gene microRNA 6400 Neighboring gene STARR-positive B cell enhancer ABC_E6155 Neighboring gene nibrin Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1638 Neighboring gene RIKEN cDNA gene A530072M11 Neighboring gene STARR-positive B cell enhancer ABC_E1028 Neighboring gene STARR-seq mESC enhancer starr_09657 Neighboring gene STARR-seq mESC enhancer starr_09658 Neighboring gene mortality factor 4 like 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11786

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    oxidative stress-induced growth inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355615.1 → NP_001342544.1  oxidative stress-induced growth inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK048731, AK148243, AL807737, BM949030, CJ182959, CJ313585
      UniProtKB/TrEMBL
      Q8BX74
      Conserved Domains (1) summary
      cl21454
      Location:118 → 339
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001355616.1 → NP_001342545.1  oxidative stress-induced growth inhibitor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK048731, AK148243, AL807737, BM949030, BP765138, CJ313585
      UniProtKB/TrEMBL
      Q91Z13
      Conserved Domains (1) summary
      cl21454
      Location:5 → 206
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_145950.5 → NP_666062.3  oxidative stress-induced growth inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_666062.3

      Status: VALIDATED

      Source sequence(s)
      AK048731, AK148243, AL807737, BM949030, CJ313585
      Consensus CDS
      CCDS17987.1
      UniProtKB/TrEMBL
      Q3TEE9, Q8BX74
      Related
      ENSMUSP00000047473.4, ENSMUST00000037198.10
      Conserved Domains (1) summary
      cl21454
      Location:217 → 378
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      15996354..16015266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253377.2 → XP_030109237.1  oxidative stress-induced growth inhibitor 2 isoform X2

      UniProtKB/TrEMBL
      Q91Z13
      Conserved Domains (1) summary
      cl21454
      Location:5 → 206
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_006537728.5 → XP_006537791.1  oxidative stress-induced growth inhibitor 2 isoform X1

      See identical proteins and their annotated locations for XP_006537791.1

      UniProtKB/TrEMBL
      Q8BX74
      Conserved Domains (1) summary
      cl21454
      Location:118 → 339
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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