U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 [ Mus musculus (house mouse) ]

    Gene ID: 108138, updated on 9-Dec-2024

    Summary

    Official Symbol
    Xrcc4provided by MGI
    Official Full Name
    X-ray repair complementing defective repair in Chinese hamster cells 4provided by MGI
    Primary source
    MGI:MGI:1333799
    See related
    Ensembl:ENSMUSG00000021615 AllianceGenome:MGI:1333799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310057B22Rik
    Summary
    Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of protection from non-homologous end joining at telomere; and telomeric DNA-containing double minutes formation. Acts upstream of or within several processes, including DNA metabolic process; hemopoiesis; and response to X-ray. Located in chromosome, telomeric region. Part of DNA-dependent protein kinase-DNA ligase 4 complex and ERCC4-ERCC1 complex. Is expressed in head; heart; and trunk. Human ortholog(s) of this gene implicated in multiple myeloma; salivary gland adenoid cystic carcinoma; and salivary gland carcinoma. Orthologous to human XRCC4 (X-ray repair cross complementing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 2.8), placenta adult (RPKM 2.8) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Xrcc4 in Genome Data Viewer
    Location:
    13 C3; 13 45.5 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (89997033..90237727, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (89848914..90089608, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene Neighboring gene versican Neighboring gene STARR-positive B cell enhancer ABC_E8538 Neighboring gene predicted gene 4117 Neighboring gene predicted gene, 50611 Neighboring gene STARR-seq mESC enhancer starr_35226 Neighboring gene STARR-seq mESC enhancer starr_35227 Neighboring gene STARR-seq mESC enhancer starr_35228 Neighboring gene STARR-seq mESC enhancer starr_35229 Neighboring gene STARR-positive B cell enhancer mm9_chr13:90229070-90229371 Neighboring gene transmembrane protein 167 Neighboring gene predicted gene, 24507 Neighboring gene predicted gene, 41013

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 37
    Process Evidence Code Pubs
    acts_upstream_of_or_within DN2 thymocyte differentiation PubMed 
    acts_upstream_of_or_within DNA ligation PubMed 
    involved_in DNA ligation involved in DNA repair  
    involved_in DNA ligation involved in DNA repair  
    involved_in DNA ligation involved in DNA repair  
    acts_upstream_of_or_within V(D)J recombination PubMed 
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within double-strand break repair PubMed 
    involved_in double-strand break repair  
    involved_in double-strand break repair via nonhomologous end joining  
    acts_upstream_of_or_within double-strand break repair via nonhomologous end joining PubMed 
    involved_in double-strand break repair via nonhomologous end joining PubMed 
    involved_in double-strand break repair via nonhomologous end joining  
    involved_in double-strand break repair via nonhomologous end joining  
    acts_upstream_of fibroblast proliferation PubMed 
    involved_in immunoglobulin V(D)J recombination  
    acts_upstream_of_or_within immunoglobulin V(D)J recombination PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within isotype switching PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of protection from non-homologous end joining at telomere PubMed 
    acts_upstream_of neurogenesis PubMed 
    acts_upstream_of neuron apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast proliferation PubMed 
    involved_in positive regulation of ligase activity  
    acts_upstream_of_or_within positive regulation of neurogenesis PubMed 
    involved_in positive regulation of phosphatidylserine exposure on apoptotic cell surface  
    involved_in positive regulation of phosphatidylserine exposure on apoptotic cell surface  
    acts_upstream_of_or_within pro-B cell differentiation PubMed 
    involved_in protein localization to site of double-strand break  
    involved_in protein localization to site of double-strand break  
    involved_in response to X-ray  
    acts_upstream_of_or_within response to X-ray PubMed 
    involved_in response to X-ray  
    acts_upstream_of_or_within response to gamma radiation PubMed 
    acts_upstream_of_or_within response to ionizing radiation PubMed 
    involved_in telomeric DNA-containing double minutes formation PubMed 
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    part_of DNA ligase IV complex  
    part_of DNA ligase IV complex  
    part_of DNA-dependent protein kinase-DNA ligase 4 complex  
    part_of DNA-dependent protein kinase-DNA ligase 4 complex PubMed 
    part_of DNA-dependent protein kinase-DNA ligase 4 complex  
    part_of ERCC4-ERCC1 complex PubMed 
    located_in chromosome, telomeric region PubMed 
    located_in cytoplasm  
    is_active_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytosol  
    part_of nonhomologous end joining complex  
    part_of nonhomologous end joining complex  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in site of double-strand break  
    located_in site of double-strand break  
    is_active_in site of double-strand break  

    General protein information

    Preferred Names
    DNA repair protein XRCC4
    Names
    X-ray repair cross-complementing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028012.4NP_082288.1  DNA repair protein XRCC4

      See identical proteins and their annotated locations for NP_082288.1

      Status: VALIDATED

      Source sequence(s)
      AK009951, AW455986, BY774472
      Consensus CDS
      CCDS26673.1
      UniProtKB/Swiss-Prot
      Q8BKC9, Q8BU02, Q924T3, Q9D6U6
      UniProtKB/TrEMBL
      A0A0R4J024
      Related
      ENSMUSP00000022115.8, ENSMUST00000022115.14
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      89997033..90237727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517041.4XP_006517104.1  DNA repair protein XRCC4 isoform X1

      See identical proteins and their annotated locations for XP_006517104.1

      UniProtKB/Swiss-Prot
      Q8BKC9, Q8BU02, Q924T3, Q9D6U6
      UniProtKB/TrEMBL
      A0A0R4J024
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4
    2. XM_006517043.5XP_006517106.1  DNA repair protein XRCC4 isoform X1

      See identical proteins and their annotated locations for XP_006517106.1

      UniProtKB/Swiss-Prot
      Q8BKC9, Q8BU02, Q924T3, Q9D6U6
      UniProtKB/TrEMBL
      A0A0R4J024
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4
    3. XM_006517042.3XP_006517105.1  DNA repair protein XRCC4 isoform X1

      See identical proteins and their annotated locations for XP_006517105.1

      UniProtKB/Swiss-Prot
      Q8BKC9, Q8BU02, Q924T3, Q9D6U6
      UniProtKB/TrEMBL
      A0A0R4J024
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4
    External link. Please review our privacy policy.