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    Retsat retinol saturase (all trans retinol 13,14 reductase) [ Mus musculus (house mouse) ]

    Gene ID: 67442, updated on 9-Dec-2024

    Summary

    Official Symbol
    Retsatprovided by MGI
    Official Full Name
    retinol saturase (all trans retinol 13,14 reductase)provided by MGI
    Primary source
    MGI:MGI:1914692
    See related
    Ensembl:ENSMUSG00000056666 AllianceGenome:MGI:1914692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMT-7; Ppsig; 0610039N19Rik
    Summary
    Enables all-trans-retinol 13,14-reductase activity. Involved in retinol metabolic process. Located in endoplasmic reticulum membrane and nuclear outer membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 119.1), kidney adult (RPKM 90.0) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Retsat in Genome Data Viewer
    Location:
    6 C1; 6 32.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72575585..72584471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72598602..72607488)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene capping actin protein, gelsolin like Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833 Neighboring gene STARR-positive B cell enhancer ABC_E6443 Neighboring gene trans-golgi network protein Neighboring gene predicted gene 15401 Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC143538

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane  
    is_active_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in nuclear membrane PubMed 
    located_in nuclear outer membrane PubMed 

    General protein information

    Preferred Names
    all-trans-retinol 13,14-reductase
    Names
    PPAR-alpha-regulated and starvation-induced gene protein
    all-trans-13,14-dihydroretinol saturase
    NP_080435.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026159.5NP_080435.3  all-trans-retinol 13,14-reductase precursor

      See identical proteins and their annotated locations for NP_080435.3

      Status: VALIDATED

      Source sequence(s)
      AC125039
      Consensus CDS
      CCDS20244.1
      UniProtKB/Swiss-Prot
      Q149J8, Q3UNN9, Q64FW2, Q78JX8, Q8VHE7, Q9CW85
      UniProtKB/TrEMBL
      A4FUU4
      Related
      ENSMUSP00000068568.7, ENSMUST00000070597.13
      Conserved Domains (2) summary
      COG1233
      Location:68566
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      cl21454
      Location:68568
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72575585..72584471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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