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    Rbp3 retinol binding protein 3, interstitial [ Mus musculus (house mouse) ]

    Gene ID: 19661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbp3provided by MGI
    Official Full Name
    retinol binding protein 3, interstitialprovided by MGI
    Primary source
    MGI:MGI:97878
    See related
    Ensembl:ENSMUSG00000041534 AllianceGenome:MGI:97878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irbp; Rbp-3
    Summary
    Predicted to enable retinol binding activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular space and interphotoreceptor matrix. Predicted to be active in cone matrix sheath. Is expressed in eye; retina; retina nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 66. Orthologous to human RBP3 (retinol binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Rbp3 in Genome Data Viewer
    Location:
    14 B; 14 20.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33675960..33686176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33954003..33964219)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 10 Neighboring gene growth differentiation factor 2 Neighboring gene zinc finger protein 488 Neighboring gene predicted gene, 30083 Neighboring gene predicted gene 5460

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Albumin is not present in the murine interphotoreceptor matrix, or in that of transgenic mice lacking IRBP. Liao R, et al. Mol Vis, 2004 Dec 30. PMID 15635294
    2. A molecular perspective on mammalian evolution from the gene encoding interphotoreceptor retinoid binding protein, with convincing evidence for bat monophyly. Stanhope MJ, et al. Mol Phylogenet Evol, 1992 Jun. PMID 1342928
    3. Light deprivation profoundly affects gene expression of interphotoreceptor retinoid-binding protein in the mouse eye. Kutty G, et al. Exp Eye Res, 1994 Jan. PMID 8157102
    4. A major cis activator of the IRBP gene contains CRX-binding and Ret-1/PCE-I elements. Boatright JH, et al. Mol Vis, 1997 Dec 22. PMID 9479006
    5. Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Xu H, et al. Eur J Immunol, 2000 Jan. PMID 10602050

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia.
      Title: Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia.
    2. These data demonstrate distinguishing features of retinal inflammation and T-cell immune responses involved in IRBP-induced EAU between B10.RIII and C57BL/6 strains.
      Title: Comparative Analysis of the Interphotoreceptor Retinoid Binding ProteinInduced Models of Experimental Autoimmune Uveitis in B10.RIII versus C57BL/6 Mice.
    3. The 629-643 RBP-3 peptide is a major uveitogenic peptide for the induction of autoimmune uveoretinitis in C57BL/6J mice and the persistent clinical disease induced with one peptide leads to epitope spreading.
      Title: A novel pathogenic RBP-3 peptide reveals epitope spreading in persistent experimental autoimmune uveoretinitis.
    4. We propose that down-regulation of IRBP may represent an early and novel pathogenic mechanism in degenerative retinal diseases
      Title: Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Müller cell disruption.
    5. Although death signaling proteins are increased, the caspase-dependent and independent apoptotic pathways are mildly activated in Irbp-deficient retinas.
      Title: Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein.
    6. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).
      Title: Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).
    7. In addition to its role in the visual cycle, IRBP is needed for normal eye development.
      Title: Exaggerated eye growth in IRBP-deficient mice in early development.
    8. IRBP is essential to normal cone function and demonstrate that differences exist in the visual cycle of rods and cones.
      Title: The interphotoreceptor retinoid binding (IRBP) is essential for normal retinoid processing in cone photoreceptors.
    9. these findings suggest that IRBP plays an important role in the delivery of 11-cis-retinol to cones and can facilitate cone function in the presence of light
      Title: Interphotoreceptor retinoid-binding protein as the physiologically relevant carrier of 11-cis-retinol in the cone visual cycle.
    10. Activation of IRBP-specific T cells from mice immunized with uveitogenic IRBP(1-20) peptide under T-helper cell interleukin (IL)17-polarizing conditions is associated with increased expansion of T cells expressing the gamma delta T cell receptor.
      Title: Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102323

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cone matrix sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interphotoreceptor matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in interphotoreceptor matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol-binding protein 3
    Names
    interphotoreceptor retinoid-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015745.3 → NP_056560.1  retinol-binding protein 3 precursor

      See identical proteins and their annotated locations for NP_056560.1

      Status: VALIDATED

      Source sequence(s)
      AC166828
      Consensus CDS
      CCDS26929.1
      UniProtKB/Swiss-Prot
      P49194, Q6B4R6, Q8VD34, Q9R0H8
      UniProtKB/TrEMBL
      A0A0R4J0H3
      Related
      ENSMUSP00000040249.9, ENSMUST00000035695.10
      Conserved Domains (1) summary
      cd07563
      Location:637 → 929
      Peptidase_S41_IRBP; Interphotoreceptor retinoid-binding protein; serine protease family S41

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33675960..33686176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49194.3 GenPept UniProtKB/Swiss-Prot:P49194

    Gene LinkOut

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