Trbv13-2 T cell receptor beta, variable 13-2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trbv13-2provided by MGI
Official Full Name: T cell receptor beta, variable 13-2provided by MGI
Primary source: MGI:MGI:98608
See related: Ensembl:ENSMUSG00000076469 IMGT/GENE-DB:TRBV13-2; AllianceGenome:MGI:98608
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcrb; TCRBV8S2; Tcrb-V8.2
Summary: Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be active in plasma membrane. Orthologous to human TRBV10-1 (T cell receptor beta variable 10-1); TRBV10-2 (T cell receptor beta variable 10-2); and TRBV10-3 (T cell receptor beta variable 10-3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 6 19.2 cM; 6 B1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (41098330..41098766)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (41121396..41121832)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of the mVbeta8.2-SEG interface allowed us to explain the higher affinity of this complex compared with the others, which may account for the early activation of T-cells bearing mVbeta8.2 by SEG
Title: Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a mouse T-cell receptor {beta} chain.
expression of spliced germline transcripts of TCR-Vbeta8.2
Title: Cell surface expression of a peptide encoded by the unrearranged TCR-Vbeta8.2 gene.
The structural basis of affinity maturation for Tcrb-V8.2 and staphylococcocal enterotoxin C3 interactin was established.
Title: Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.