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Igf1 insulin-like growth factor 1 [ Mus musculus (house mouse) ]

Gene ID: 16000, updated on 17-Dec-2024

Summary

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Official Symbol: Igf1provided by MGI
Official Full Name: insulin-like growth factor 1provided by MGI
Primary source: MGI:MGI:96432
See related: Ensembl:ENSMUSG00000020053 AllianceGenome:MGI:96432
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igf-1; Igf-I; C730016P09Rik
Summary: This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Expression: Biased expression in liver adult (RPKM 36.1), subcutaneous fat pad adult (RPKM 12.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

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See Igf1 in Genome Data Viewer

Location:: 10 C1; 10 43.7 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (87694127..87772909)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (87858265..87937047)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice.
Title: Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice.
Targeting IGF1/IGF1r signaling relieve pain and autophagic dysfunction in NTG-induced chronic migraine model of mice.
Title: Targeting IGF1/IGF1r signaling relieve pain and autophagic dysfunction in NTG-induced chronic migraine model of mice.
The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice.
Title: The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice.
Identification of IGF-1 Effects on White Adipose Tissue and Hippocampus in Alzheimer's Disease Mice via Transcriptomic and Cellular Analysis.
Title: Identification of IGF-1 Effects on White Adipose Tissue and Hippocampus in Alzheimer's Disease Mice via Transcriptomic and Cellular Analysis.
Mrc1[+] macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway.
Title: Mrc1(+) macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway.
Suppression of Overactive Insulin-Like Growth Factor 1 Attenuates Trauma-Induced Heterotopic Ossification in Mice.
Title: Suppression of Overactive Insulin-Like Growth Factor 1 Attenuates Trauma-Induced Heterotopic Ossification in Mice.
Complementary role of peripheral and central autonomic nervous system on insulin-like growth factor-1 activation to prevent fatty liver disease.
Title: Complementary role of peripheral and central autonomic nervous system on insulin-like growth factor-1 activation to prevent fatty liver disease.
Microglia-Derived Insulin-like Growth Factor 1 Is Critical for Neurodevelopment.
Title: Microglia-Derived Insulin-like Growth Factor 1 Is Critical for Neurodevelopment.
Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition.
Title: Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition.
Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration.
Title: Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration.

Submit: New GeneRIF Correction See all GeneRIFs (651)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (12) 1 citation

General gene information

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Markers

Igf1 (e-PCR), detects polymorphism
- UniSTS:526082

Igf1 (e-PCR), detects polymorphism
- UniSTS:531475

PMC151128P1 (e-PCR)
- UniSTS:271138

Igf1 (e-PCR), detects polymorphism
- UniSTS:545862

D7Rat226 (e-PCR), detects polymorphism
- UniSTS:228174

Igf1 (e-PCR), detects polymorphism
- UniSTS:516198

Igf1 (e-PCR), detects polymorphism
- UniSTS:143466

Igf1 (e-PCR), detects polymorphism
- UniSTS:143467

Igf1 (e-PCR), detects polymorphism
- UniSTS:143468

Igf1 (e-PCR), detects polymorphism
- UniSTS:143469

Igf1 (e-PCR), detects polymorphism
- UniSTS:506995

NoName (e-PCR)
- UniSTS:236429

GDB:384821 (e-PCR)
- UniSTS:157100

Igf1 (e-PCR), detects polymorphism
- UniSTS:516546

Igf1 (e-PCR), detects polymorphism
- UniSTS:502725

Igf1 (e-PCR), detects polymorphism
- UniSTS:259553

Igf1 (e-PCR), detects polymorphism
- UniSTS:465393

MARC_16386-16387:1017081416:1 (e-PCR)
- UniSTS:268018

D7Mit23 (e-PCR), detects polymorphism
- UniSTS:118003

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IGI Inferred from Genetic Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell activation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to insulin-like growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within lung alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung lobe morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung lobe morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in myotube cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cholangiocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immune system process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of trophectodermal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland epithelium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland growth	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within prostate gland growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland stromal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment or maintenance of cell polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intracellular steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in retinal cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of smell	TAS Traceable Author Statement more info	PubMed
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of type B pancreatic cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within type I pneumocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type II pneumocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	ISO Inferred from Sequence Orthology more info
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	ISS Inferred from Sequence or Structural Similarity more info
located_in exocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of insulin-like growth factor ternary complex	ISO Inferred from Sequence Orthology more info
part_of insulin-like growth factor ternary complex	ISS Inferred from Sequence or Structural Similarity more info
part_of insulin-like growth factor ternary complex	TAS Traceable Author Statement more info	PubMed
located_in interstitial matrix	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle lumen	IMP Inferred from Mutant Phenotype more info	PubMed
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 1; insulin-like growth factor I

Names: somatomedin

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111274.1 → NP_001104744.1 insulin-like growth factor 1 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation from a distinct start codon and result in an isoform (3) with a novel N-terminus, compared to isoform 1. This isoform (3) is also known as IIB. This isoform (3) may undergo proteolytic processing similar to isoform 4.

Source sequence(s)

AC139754, AK038119, CT010364

Consensus CDS

CCDS48662.1

UniProtKB/TrEMBL

D3Z7M4, E9PU89

Related

ENSMUSP00000112878.2, ENSMUST00000122100.3

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
NM_001111275.2 → NP_001104745.1 insulin-like growth factor 1 isoform 4 preproprotein

See identical proteins and their annotated locations for NP_001104745.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. This isoform (4) is also known as IA.

Source sequence(s)

AC125082, AC139754, AK081019

Consensus CDS

CCDS48661.1

UniProtKB/Swiss-Prot

P05017, P05018, Q6LDP4, Q8C4U6

UniProtKB/TrEMBL

Q4VJC0, Q547V2

Related

ENSMUSP00000093005.5, ENSMUST00000095360.11

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
NM_001111276.1 → NP_001104746.1 insulin-like growth factor 1 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a distinct start codon and result in an isoform (5) with novel N- and C-termini, compared to isoform 1. This isoform (5) is also known as IIA. This isoform (5) may undergo proteolytic processing similar to isoform 4.

Source sequence(s)

AC139754, AK038119, CT010364

Consensus CDS

CCDS48663.1

UniProtKB/TrEMBL

E9Q138, Q547V2

Related

ENSMUSP00000114120.2, ENSMUST00000121161.8

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
NM_001314010.1 → NP_001300939.1 insulin-like growth factor 1 isoform 4 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. This isoform (4) is also known as IA.

Source sequence(s)

AC125082, AC139754, AK081019

Consensus CDS

CCDS48661.1

UniProtKB/Swiss-Prot

P05017, P05018, Q6LDP4, Q8C4U6

UniProtKB/TrEMBL

Q4VJC0, Q547V2

Related

ENSMUSP00000113905.2, ENSMUST00000122386.8

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
NM_010512.5 → NP_034642.2 insulin-like growth factor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_034642.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This isoform (1) is also known as IB. This isoform (1) may undergo proteolytic processing similar to isoform 4.

Source sequence(s)

AC125082, AC139754, AI019109, AK081019

Consensus CDS

CCDS24104.2

UniProtKB/TrEMBL

D3Z7M4, Q4VJB9

Related

ENSMUSP00000100937.3, ENSMUST00000105300.9

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

87694127..87772909

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244906.1 → XP_030100766.1 insulin-like growth factor I isoform X4

Conserved Domains (1) summary

cd04368
Location:64 → 131

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_006513264.4 → XP_006513327.1 insulin-like growth factor I isoform X10

UniProtKB/TrEMBL

D3Z7M4

Conserved Domains (1) summary

cd04368
Location:34 → 101

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_030244911.1 → XP_030100771.1 insulin-like growth factor I isoform X12

UniProtKB/TrEMBL

Q547V2

Conserved Domains (1) summary

cd04368
Location:34 → 101

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_006513257.1 → XP_006513320.1 insulin-like growth factor I isoform X2

See identical proteins and their annotated locations for XP_006513320.1

Conserved Domains (1) summary

cd04368
Location:87 → 154

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_006513255.3 → XP_006513318.1 insulin-like growth factor I isoform X1

See identical proteins and their annotated locations for XP_006513318.1

Conserved Domains (1) summary

cd04368
Location:87 → 154

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_030244907.1 → XP_030100767.1 insulin-like growth factor I isoform X5

Conserved Domains (1) summary

cd04368
Location:64 → 131

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_006513258.3 → XP_006513321.1 insulin-like growth factor I isoform X6

Conserved Domains (1) summary

cd04368
Location:57 → 124

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_030244908.2 → XP_030100768.1 insulin-like growth factor I isoform X7

Conserved Domains (1) summary

cd04368
Location:57 → 124

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_030244910.1 → XP_030100770.1 insulin-like growth factor I isoform X9

UniProtKB/TrEMBL

Q547V2

Conserved Domains (1) summary

cd04368
Location:46 → 113

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_006513262.3 → XP_006513325.1 insulin-like growth factor I isoform X8

UniProtKB/TrEMBL

D3Z7M4

Conserved Domains (1) summary

cd04368
Location:46 → 113

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_017313810.2 → XP_017169299.1 insulin-like growth factor I isoform X3

Conserved Domains (1) summary

cd04368
Location:76 → 143

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_017313812.3 → XP_017169301.1 insulin-like growth factor I isoform X11

UniProtKB/TrEMBL

D3Z7M4, E9PU89

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_017313811.1 → XP_017169300.1 insulin-like growth factor I isoform X11

UniProtKB/TrEMBL

D3Z7M4, E9PU89

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_030244912.2 → XP_030100772.1 insulin-like growth factor I isoform X13

UniProtKB/TrEMBL

E9Q138, Q547V2

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_036155648.1 → XP_036011541.1 insulin-like growth factor I isoform X11

UniProtKB/TrEMBL

D3Z7M4, E9PU89

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_184052.3: Suppressed sequence

Description

NM_184052.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.