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    Rnf39 ring finger protein 39 [ Mus musculus (house mouse) ]

    Gene ID: 386454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf39provided by MGI
    Official Full Name
    ring finger protein 39provided by MGI
    Primary source
    MGI:MGI:2156378
    See related
    Ensembl:ENSMUSG00000036492 AllianceGenome:MGI:2156378
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LIRF; Gm320; Gm1786; Gm1787
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Orthologous to human RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 18.8), lung adult (RPKM 17.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf39 in Genome Data Viewer
    Location:
    17 B1; 17 19.16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37253943..37258878)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36943051..36947986)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 31 Neighboring gene RIKEN cDNA 1700031A10 gene Neighboring gene predicted gene, 33595 Neighboring gene STARR-positive B cell enhancer ABC_E7532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37088519-37088789 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37095409-37095518 Neighboring gene RNA polymerase I subunit H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity. Wang W, et al. Sci Adv, 2021 Mar. PMID 33674311, Free PMC Article
    2. RNF39 facilitates antiviral immune responses by promoting K63-linked ubiquitination of STING. Wang W, et al. Int Immunopharmacol, 2024 Dec 5. PMID 39255680
    3. LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein. Matsuo R, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716498
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF39 facilitates antiviral immune responses by promoting K63-linked ubiquitination of STING.
      Title: RNF39 facilitates antiviral immune responses by promoting K63-linked ubiquitination of STING.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099632.1 → NP_001093102.1  RING finger protein 39

      See identical proteins and their annotated locations for NP_001093102.1

      Status: PROVISIONAL

      Source sequence(s)
      BC145677
      Consensus CDS
      CCDS50103.1
      UniProtKB/TrEMBL
      A2RT81
      Related
      ENSMUSP00000037860.6, ENSMUST00000040498.12
      Conserved Domains (3) summary
      cd00162
      Location:19 → 70
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02614
      Location:161 → 347
      SPRY; SPRY domain
      cl11399
      Location:119 → 154
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37253943..37258878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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