Folr2 folate receptor beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Folr2provided by MGI
Official Full Name: folate receptor betaprovided by MGI
Primary source: MGI:MGI:95569
See related: Ensembl:ENSMUSG00000032725 AllianceGenome:MGI:95569
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBP2; FR-P3; Folbp2; FR-beta; Folbp-2
Summary: This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression: Biased expression in mammary gland adult (RPKM 34.0), subcutaneous fat pad adult (RPKM 24.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101489195..101506397, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (101839988..101857190, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.
Title: Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.
(18)F-AzaFol for Detection of Folate Receptor-beta Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study.
Title: (18)F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study.
The characteristics of folate transport in oocytes are consistent with folate receptor-mediated endocytosis, possibly by the FOLR2 isoform.
Title: Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size.
FRbeta expression was markedly increased in lung macrophages at 48 hours after intratracheal LPS.
Title: Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation.
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cell embryos and blastocysts.
Title: Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.
Folbp2 null cells display increased sensitivity to arsenic exposure
Title: Differential effects of arsenic on folate binding protein 2 (Folbp2) null and wild type fibroblasts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Folr2 (e-PCR), detects polymorphism
- UniSTS:205456

NoName (e-PCR)
- UniSTS:235729

NoName (e-PCR)
- UniSTS:548576

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables folic acid binding	ISO Inferred from Sequence Orthology more info
enables folic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables folic acid binding	TAS Traceable Author Statement more info	PubMed
enables folic acid receptor activity	ISO Inferred from Sequence Orthology more info
enables folic acid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables folic acid receptor activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to folic acid	IEA Inferred from Electronic Annotation more info
involved_in folic acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
involved_in sperm-egg recognition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: folate receptor beta

Names: folate binding protein 2; folate receptor 2 (fetal)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303231.1 → NP_001290160.1 folate receptor beta precursor

See identical proteins and their annotated locations for NP_001290160.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-3) encode the same protein.

Source sequence(s)

AC159005

Consensus CDS

CCDS21516.1

UniProtKB/Swiss-Prot

Q05685

Conserved Domains (1) summary

pfam03024
Location:29 → 203

Folate_rec; Folate receptor family
NM_001303239.1 → NP_001290168.1 folate receptor beta precursor

See identical proteins and their annotated locations for NP_001290168.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All variants (1-3) encode the same protein.

Source sequence(s)

AC159005, AC167240, BQ176722

Consensus CDS

CCDS21516.1

UniProtKB/Swiss-Prot

Q05685

Related

ENSMUSP00000147920.2, ENSMUST00000210598.2

Conserved Domains (1) summary

pfam03024
Location:29 → 203

Folate_rec; Folate receptor family
NM_008035.2 → NP_032061.1 folate receptor beta precursor

See identical proteins and their annotated locations for NP_032061.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-3) encode the same protein.

Source sequence(s)

AC159005, BQ176722, CJ049116

Consensus CDS

CCDS21516.1

UniProtKB/Swiss-Prot

Q05685

Related

ENSMUSP00000091692.6, ENSMUST00000094141.7

Conserved Domains (1) summary

pfam03024
Location:29 → 203

Folate_rec; Folate receptor family