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    Pgm2 phosphoglucomutase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgm2provided by MGI
    Official Full Name
    phosphoglucomutase 2provided by MGI
    Primary source
    MGI:MGI:97564
    See related
    Ensembl:ENSMUSG00000029171 AllianceGenome:MGI:97564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgm1; Pgm-1; 3230402E02Rik
    Summary
    Enables phosphoglucomutase activity. Involved in glycogen biosynthetic process and glycogen catabolic process. Acts upstream of or within glucose metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; liver; oocyte; respiratory system; and telencephalon. Orthologous to human PGM2 (phosphoglucomutase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: The name of this locus, Pgm2, was recently updated by Mouse Genomic Informatics to be consistent with mammalian orthologs identified as Pgm2. Note that this gene is frequently referred to as Pgm1 in the literature. [02 Oct 2019]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 10.1), large intestine adult (RPKM 9.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgm2 in Genome Data Viewer
    Location:
    5 C3.1; 5 32.8 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (64250258..64285698)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (64092919..64128355)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13191 Neighboring gene STARR-seq mESC enhancer starr_13192 Neighboring gene STARR-seq mESC enhancer starr_13193 Neighboring gene predicted gene, 25608 Neighboring gene STARR-positive B cell enhancer mm9_chr5:64431930-64432231 Neighboring gene RIKEN cDNA 5830416I19 gene Neighboring gene STARR-positive B cell enhancer ABC_E9641 Neighboring gene STARR-positive B cell enhancer ABC_E6330 Neighboring gene STARR-seq mESC enhancer starr_13198 Neighboring gene STARR-positive B cell enhancer mm9_chr5:64540539-64540839 Neighboring gene STARR-positive B cell enhancer ABC_E2744 Neighboring gene predicted gene, 22559 Neighboring gene TBC1 domain family, member 1 Neighboring gene STARR-seq mESC enhancer starr_13200 Neighboring gene predicted gene 15824

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological correlates of an enzyme polymorphism. Brown AJ. Nature, 1977 Oct 27. PMID 927504
    2. TEM-induced gene mutations at enzyme loci in the mouse. Soares ER. Environ Mutagen, 1979. PMID 162283
    3. A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality. Balakrishnan B, et al. J Inherit Metab Dis, 2019 Sep. PMID 31077402, Free PMC Article
    4. Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5. Ihle JN, et al. Science, 1979 Apr 6. PMID 219476
    5. The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells. Myers SA, et al. PLoS One, 2013. PMID 24265765, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (4) 
    • Chemically induced (other) (1)  1 citation
    • Endonuclease-mediated (3) 
    • Spontaneous (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglucomutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoglucomutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoglucomutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphopentomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopentomutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphopentomutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine ribonucleoside salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphoglucomutase-2
    Names
    glucose phosphomutase 2
    phosphodeoxyribomutase
    phosphoglucomutase 1
    phosphopentomutase
    NP_001343893.1
    NP_079976.1
    XP_006504121.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356964.2 → NP_001343893.1  phosphoglucomutase-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132271
      Conserved Domains (1) summary
      PTZ00150
      Location:1 → 558
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    2. NM_001429268.1 → NP_001416197.1  phosphoglucomutase-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132271

    3. NM_025700.4 → NP_079976.1  phosphoglucomutase-2 isoform 1

      See identical proteins and their annotated locations for NP_079976.1

      Status: VALIDATED

      Source sequence(s)
      AC132271
      Consensus CDS
      CCDS19300.1
      UniProtKB/Swiss-Prot
      Q7TSV4, Q8K0P7, Q9CRS8
      Related
      ENSMUSP00000084582.6, ENSMUST00000087324.7
      Conserved Domains (1) summary
      PTZ00150
      Location:19 → 620
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      64250258..64285698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504058.3 → XP_006504121.1  phosphoglucomutase-2 isoform X1

      Conserved Domains (1) summary
      PTZ00150
      Location:1 → 452
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    RNA

    1. XR_004942550.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSV4.1 GenPept UniProtKB/Swiss-Prot:Q7TSV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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