Flrt2 fibronectin leucine rich transmembrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flrt2provided by MGI
Official Full Name: fibronectin leucine rich transmembrane protein 2provided by MGI
Primary source: MGI:MGI:3603594
See related: Ensembl:ENSMUSG00000047414 AllianceGenome:MGI:3603594
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in basement membrane organization; cell adhesion involved in heart morphogenesis; and fibroblast growth factor receptor signaling pathway. Acts upstream of or within axon guidance; positive regulation of synapse assembly; and regulation of neuron migration. Located in cell-cell junction; extracellular space; and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 8.9), CNS E14 (RPKM 5.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 46.44 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (95658780..95751989)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (95692006..95785215)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
Title: FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis.
Title: Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis.
Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.
Title: Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.
FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
Title: FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
The Flrt2 regulates osteoclast multinucleation by interfering with Netrin 1-Unc5b interaction and may be a suitable therapeutic target for diseases associated with bone remodeling.
Title: Flrt2 is involved in fine-tuning of osteoclast multinucleation.
The observations propose that FLRT2 can regulate memory functions in the adulthood in a sex-specific manner and might thus contribute to further research on the mechanisms linking sexual dimorphism and cognition.
Title: Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice.
fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.
Title: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.
Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion.
Title: Super-complexes of adhesion GPCRs and neural guidance receptors.
FLRT2 may exist in both membrane-bound and shed forms which interact with fibronectin in the ATDC5 chondroprogenitor cells.
Title: FLRT2 interacts with fibronectin in the ATDC5 chondroprogenitor cells.
findings provide evidence for a role of FLRT2 in enhancing cell proliferation and reducing intercellular adhesion during the early stages of chondrogenesis
Title: FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Flrt2 (e-PCR), detects polymorphism
- UniSTS:497482

D12Mit164 (e-PCR), detects polymorphism
- UniSTS:126719

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemorepellent activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat transmembrane protein FLRT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001422812.1 → NP_001409741.1 leucine-rich repeat transmembrane protein FLRT2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC122430, AC125487

UniProtKB/Swiss-Prot

Q6A073, Q8BLU0

UniProtKB/TrEMBL

Q3UVS6

Related

ENSMUSP00000105744.2, ENSMUST00000110117.2
NM_201518.4 → NP_958926.1 leucine-rich repeat transmembrane protein FLRT2 isoform 1 precursor

See identical proteins and their annotated locations for NP_958926.1

Status: VALIDATED

Source sequence(s)

AC122430, AC125487

Consensus CDS

CCDS26094.1

UniProtKB/Swiss-Prot

Q6A073, Q8BLU0

UniProtKB/TrEMBL

Q3UVS6

Related

ENSMUSP00000062171.4, ENSMUST00000057324.4

Conserved Domains (6) summary

PRK15370
Location:26 → 265

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:282 → 359

PCC; polycystin cation channel protein

sd00031
Location:65 → 86

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:90 → 110

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:426 → 494

fn3; Fibronectin type III domain

pfam13855
Location:252 → 311

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

95658780..95751989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244132.3 → XP_011242434.1 leucine-rich repeat transmembrane protein FLRT2 isoform X1

See identical proteins and their annotated locations for XP_011242434.1

UniProtKB/Swiss-Prot

Q6A073, Q8BLU0

UniProtKB/TrEMBL

Q3UVS6

Conserved Domains (6) summary

PRK15370
Location:26 → 265

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:282 → 359

PCC; polycystin cation channel protein

sd00031
Location:65 → 86

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:90 → 110

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:426 → 494

fn3; Fibronectin type III domain

pfam13855
Location:252 → 311

LRR_8; Leucine rich repeat
XM_036157517.1 → XP_036013410.1 leucine-rich repeat transmembrane protein FLRT2 isoform X1

UniProtKB/Swiss-Prot

Q6A073, Q8BLU0

UniProtKB/TrEMBL

Q3UVS6

Conserved Domains (6) summary

PRK15370
Location:26 → 265

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:282 → 359

PCC; polycystin cation channel protein

sd00031
Location:65 → 86

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:90 → 110

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:426 → 494

fn3; Fibronectin type III domain

pfam13855
Location:252 → 311

LRR_8; Leucine rich repeat
XM_036157518.1 → XP_036013411.1 leucine-rich repeat transmembrane protein FLRT2 isoform X1

UniProtKB/Swiss-Prot

Q6A073, Q8BLU0

UniProtKB/TrEMBL

Q3UVS6

Conserved Domains (6) summary

PRK15370
Location:26 → 265

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:282 → 359

PCC; polycystin cation channel protein

sd00031
Location:65 → 86

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:90 → 110

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:426 → 494

fn3; Fibronectin type III domain

pfam13855
Location:252 → 311

LRR_8; Leucine rich repeat