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    Adcy1 adenylate cyclase 1 [ Mus musculus (house mouse) ]

    Gene ID: 432530, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adcy1provided by MGI
    Official Full Name
    adenylate cyclase 1provided by MGI
    Primary source
    MGI:MGI:99677
    See related
    Ensembl:ENSMUSG00000020431 AllianceGenome:MGI:99677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AC1; brl; I-AC; D11Bwg1392e
    Summary
    Enables adenylate cyclase activity. Involved in several processes, including modulation of chemical synaptic transmission; neuroinflammatory response; and positive regulation of CREB transcription factor activity. Acts upstream of or within axonogenesis and long-term memory. Located in cytoplasm and postsynaptic density. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 78.9), cortex adult (RPKM 50.8) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Adcy1 in Genome Data Viewer
    Location:
    11 A1; 11 4.72 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (7013433..7128506)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (7063433..7178506)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57582 Neighboring gene STARR-seq mESC enhancer starr_28478 Neighboring gene STARR-seq mESC enhancer starr_28479 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28481 Neighboring gene STARR-seq mESC enhancer starr_28484 Neighboring gene coiled coil domain 201 Neighboring gene insulin-like growth factor binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA4070

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables adenylate cyclase activity  
    enables adenylate cyclase activity PubMed 
    enables adenylate cyclase activity PubMed 
    enables calcium- and calmodulin-responsive adenylate cyclase activity  
    enables calcium- and calmodulin-responsive adenylate cyclase activity  
    enables calmodulin binding  
    enables metal ion binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of adenylate cyclase activity PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within axonogenesis PubMed 
    involved_in cAMP biosynthetic process  
    involved_in cAMP biosynthetic process  
    involved_in cAMP biosynthetic process  
    involved_in cellular response to calcium ion  
    involved_in cellular response to forskolin  
    involved_in circadian rhythm  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within long-term memory PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in neuroinflammatory response PubMed 
    involved_in positive regulation of CREB transcription factor activity PubMed 
    involved_in positive regulation of long-term synaptic potentiation PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in regulation of circadian rhythm PubMed 
    involved_in response to xenobiotic stimulus  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in cytoplasm PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
    located_in membrane raft  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynaptic density PubMed 
    is_active_in postsynaptic density membrane PubMed 
    is_active_in postsynaptic density membrane PubMed 
    located_in presynapse  

    General protein information

    Preferred Names
    adenylate cyclase type 1
    Names
    ATP pyrophosphate-lyase 1
    Ca(2+)/calmodulin-activated adenylyl cyclase
    adenylate cyclase type I
    adenylyl cyclase 1
    barrelless
    NP_033752.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009622.2NP_033752.1  adenylate cyclase type 1

      See identical proteins and their annotated locations for NP_033752.1

      Status: VALIDATED

      Source sequence(s)
      AL669838
      Consensus CDS
      CCDS24426.1
      UniProtKB/Swiss-Prot
      O88444, Q5SS89
      Related
      ENSMUSP00000020706.5, ENSMUST00000020706.5
      Conserved Domains (3) summary
      smart00044
      Location:257452
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:8581055
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:158291
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      7013433..7128506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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