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    Wfdc6a WAP four-disulfide core domain 6A [ Mus musculus (house mouse) ]

    Gene ID: 209351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wfdc6aprovided by MGI
    Official Full Name
    WAP four-disulfide core domain 6Aprovided by MGI
    Primary source
    MGI:MGI:2684968
    See related
    Ensembl:ENSMUSG00000074595 AllianceGenome:MGI:2684968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm122
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of calcium ion import; negative regulation of flagellated sperm motility; and negative regulation of peptidase activity. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Orthologous to human EPPIN (epididymal peptidase inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 40.6) See more
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    Genomic context

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    See Wfdc6a in Genome Data Viewer
    Location:
    2 H3; 2 85.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164421439..164427704, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164579519..164585784, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 2 Neighboring gene serine peptidase inhibitor, Kunitz type, 3 Neighboring gene epididymal peptidase inhibitor Neighboring gene WAP four-disulfide core domain 8 Neighboring gene predicted gene, 25512

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†. Andrade AD, et al. Biol Reprod, 2021 Jan 4. PMID 33034631
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WAP four-disulfide core domain protein 6A
    Names
    likely orthologue of H. sapiens WAP four-disulfide core domain 6 (WFDC6)
    putative protease inhibitor WAP6A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033240.4 → NP_001028412.1  WAP four-disulfide core domain protein 6A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001028412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL591478, BC147597, BM933122
      Consensus CDS
      CCDS17042.1
      UniProtKB/Swiss-Prot
      Q3UW55
      Related
      ENSMUSP00000104966.2, ENSMUST00000109342.2
      Conserved Domains (2) summary
      pfam00014
      Location:76 → 128
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:32 → 71
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    2. NM_001177848.1 → NP_001171319.1  WAP four-disulfide core domain protein 6A isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK136589, AL591478, BC147597
      UniProtKB/Swiss-Prot
      Q3UW55
      Related
      ENSMUSP00000096694.3, ENSMUST00000099096.9
      Conserved Domains (2) summary
      pfam00014
      Location:86 → 138
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:42 → 81
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164421439..164427704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239408.3 → XP_011237710.1  WAP four-disulfide core domain protein 6A isoform X1

      Conserved Domains (2) summary
      pfam00014
      Location:133 → 184
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:89 → 128
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    2. XM_006499076.3 → XP_006499139.1  WAP four-disulfide core domain protein 6A isoform X2

      Conserved Domains (2) summary
      pfam00014
      Location:93 → 144
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:49 → 88
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UW55.1 GenPept UniProtKB/Swiss-Prot:Q3UW55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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