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    ZNF442 zinc finger protein 442 [ Homo sapiens (human) ]

    Gene ID: 79973, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF442provided by HGNC
    Official Full Name
    zinc finger protein 442provided by HGNC
    Primary source
    HGNC:HGNC:20877
    See related
    Ensembl:ENSG00000198342 AllianceGenome:HGNC:20877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.4), thyroid (RPKM 0.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF442 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12345944..12373779, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12474291..12502125, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12456758..12476497, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 44 Neighboring gene ribosomal protein L28 pseudogene 5 Neighboring gene MPRA-validated peak3363 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14048 Neighboring gene ribosomal protein S2 pseudogene 53 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12444503-12445368 Neighboring gene zinc finger protein 563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14052 Neighboring gene ribosomal protein S29 pseudogene 23 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12501177-12501678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14054 Neighboring gene zinc finger protein 799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10150 Neighboring gene zinc finger protein 443

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
    2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ14356

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 442

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363774.2 → NP_001350703.1  zinc finger protein 442 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008758, AK295923, DA151257, DC395131
      Consensus CDS
      CCDS86707.1
      Related
      ENSP00000388634.1, ENST00000438182.5
      Conserved Domains (2) summary
      COG5048
      Location:166 → 553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:449 → 469
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_030824.3 → NP_110451.1  zinc finger protein 442 isoform 1

      See identical proteins and their annotated locations for NP_110451.1

      Status: VALIDATED

      Source sequence(s)
      AC008758, AK024418, DA151257
      Consensus CDS
      CCDS12271.1
      UniProtKB/Swiss-Prot
      B4DJ48, Q9H7R0
      Related
      ENSP00000242804.4, ENST00000242804.9
      Conserved Domains (5) summary
      smart00349
      Location:29 → 69
      KRAB; krueppel associated box
      COG5048
      Location:160 → 563
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:29 → 65
      KRAB; KRAB box
      pfam13465
      Location:307 → 332
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12345944..12373779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027317.2 → XP_016882806.1  zinc finger protein 442 isoform X1

    2. XM_006722908.4 → XP_006722971.1  zinc finger protein 442 isoform X2

      See identical proteins and their annotated locations for XP_006722971.1

      Conserved Domains (5) summary
      smart00349
      Location:22 → 62
      KRAB; krueppel associated box
      COG5048
      Location:153 → 556
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:511 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:22 → 58
      KRAB; KRAB box
      pfam13465
      Location:300 → 325
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017027316.2 → XP_016882805.2  zinc finger protein 442 isoform X1

    RNA

    1. XR_007067014.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12474291..12502125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322216.1 → XP_054178191.1  zinc finger protein 442 isoform X1

    2. XM_054322215.1 → XP_054178190.1  zinc finger protein 442 isoform X2

    3. XM_054322214.1 → XP_054178189.1  zinc finger protein 442 isoform X1

    RNA

    1. XR_008485203.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H7R0.1 GenPept UniProtKB/Swiss-Prot:Q9H7R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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