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    UBAP2 ubiquitin associated protein 2 [ Homo sapiens (human) ]

    Gene ID: 55833, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UBAP2provided by HGNC
    Official Full Name
    ubiquitin associated protein 2provided by HGNC
    Primary source
    HGNC:HGNC:14185
    See related
    Ensembl:ENSG00000137073 AllianceGenome:HGNC:14185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBAP-2
    Summary
    The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in testis (RPKM 18.9), adrenal (RPKM 7.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UBAP2 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33921693..34049199, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33940293..34067767, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33921691..34049197, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene UBE2R2 antisense RNA 1 Neighboring gene serine protease 3 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33796108-33796608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19839 Neighboring gene ubiquitin conjugating enzyme E2 R2 Neighboring gene RNA, U4atac small nuclear 11, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33927431-33928421 Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene small nucleolar RNA, C/D box 121A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33988845-33989346 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 8 Neighboring gene MPRA-validated peak7224 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34033238-34034231 Neighboring gene RNA, U7 small nuclear 36 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34047995-34048851 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34048852-34049707 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34049708-34050564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34050565-34051419 Neighboring gene RN7SK pseudogene 114 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene TUBB4B pseudogene 2 Neighboring gene tubulin beta pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. Hofmann K, et al. Trends Biochem Sci, 1996 May. PMID 8871400
    2. Circ-UBAP2 functions as sponges of miR-1205 and miR-382 to promote glioma progression by modulating STC1 expression. Wang J, et al. Cancer Med, 2021 Mar. PMID 33543830, Free PMC Article
    3. [Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells and Its Mechanism]. Yin Y, et al. Zhongguo Fei Ai Za Zhi, 2017 Dec 20. PMID 29277177, Free PMC Article
    4. Amplification of the 9p13.3 chromosomal region in prostate cancer. Latonen L, et al. Genes Chromosomes Cancer, 2016 Aug. PMID 27074291
    5. UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2. Bai DS, et al. Oncotarget, 2016 May 31. PMID 27121050, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating the miR-143/TFAP2B Axis in Prostate Cancer.
      Title: Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating the miR-143/TFAP2B Axis in Prostate Cancer.
    2. PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
      Title: PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
    3. UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.
      Title: UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.
    4. Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells.
      Title: Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells.
    5. Circ-UBAP2 functions as sponges of miR-1205 and miR-382 to promote glioma progression by modulating STC1 expression.
      Title: Circ-UBAP2 functions as sponges of miR-1205 and miR-382 to promote glioma progression by modulating STC1 expression.
    6. circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis.
      Title: circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis.
    7. Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer.
      Title: Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer.
    8. The circ-UBAP2 plays a vital regulatory role in triple-negative breast cancer (TNBC) via the miR-661/MTA1 axis and may serve as a promising therapeutic target for TNBC patients.
      Title: Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway.
    9. Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells
      Title: [Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells and Its Mechanism].
    10. UBAP2 formed a complex with Annexin A2 and promoted the degradation of Annexin A2 protein by ubiquitination, and then inhibited HCC progression.
      Title: UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated ubiquitin associated protein 2 (UBAP2) is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22435, FLJ43947, FLJ46567, KIAA1491

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated protein 2
    Names
    AD-012 protein
    RNA polymerase II degradation factor UBAP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282530.2 → NP_001269459.1  ubiquitin-associated protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001269459.1

      Status: REVIEWED

      Source sequence(s)
      AL139113
      UniProtKB/TrEMBL
      B3KQ73

    2. NM_001370059.2 → NP_001356988.2  ubiquitin-associated protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      Consensus CDS
      CCDS6547.1
      UniProtKB/Swiss-Prot
      Q2M2R4, Q5JV03, Q5T6F2, Q6PK34, Q8NC94, Q9P237
      UniProtKB/TrEMBL
      A0A8C8KGQ8
      Related
      ENSP00000507293.1, ENST00000682239.1
      Conserved Domains (2) summary
      cd14277
      Location:53 → 90
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:512 → 541
      DUF3697; Ubiquitin-associated protein 2

    3. NM_001370062.2 → NP_001356991.2  ubiquitin-associated protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      Consensus CDS
      CCDS6547.1
      UniProtKB/Swiss-Prot
      Q2M2R4, Q5JV03, Q5T6F2, Q6PK34, Q8NC94, Q9P237
      UniProtKB/TrEMBL
      A0A8C8KGQ8
      Related
      ENSP00000368540.2, ENST00000379238.7
      Conserved Domains (2) summary
      cd14277
      Location:53 → 90
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:512 → 541
      DUF3697; Ubiquitin-associated protein 2

    4. NM_001370064.2 → NP_001356993.2  ubiquitin-associated protein 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      UniProtKB/TrEMBL
      B4DZ54
      Conserved Domains (2) summary
      cd14277
      Location:15 → 52
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:421 → 450
      DUF3697; Ubiquitin-associated protein 2

    5. NM_001370066.2 → NP_001356995.2  ubiquitin-associated protein 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      UniProtKB/TrEMBL
      B4DZ54
      Conserved Domains (2) summary
      cd14277
      Location:15 → 52
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:474 → 503
      DUF3697; Ubiquitin-associated protein 2

    6. NM_001370067.2 → NP_001356996.2  ubiquitin-associated protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      Consensus CDS
      CCDS6548.1
      UniProtKB/TrEMBL
      A0A8C8KGQ8, A0A8C8MQ70
      Related
      ENSP00000368541.6, ENST00000379239.9
      Conserved Domains (2) summary
      cd14277
      Location:53 → 90
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:459 → 488
      DUF3697; Ubiquitin-associated protein 2

    7. NM_001370068.2 → NP_001356997.2  ubiquitin-associated protein 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      UniProtKB/TrEMBL
      B4DZ54
      Conserved Domains (2) summary
      cd14277
      Location:15 → 52
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:474 → 503
      DUF3697; Ubiquitin-associated protein 2

    8. NM_018449.4 → NP_060919.4  ubiquitin-associated protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      Consensus CDS
      CCDS6547.1
      UniProtKB/Swiss-Prot
      Q2M2R4, Q5JV03, Q5T6F2, Q6PK34, Q8NC94, Q9P237
      UniProtKB/TrEMBL
      A0A8C8KGQ8

    9. NM_020867.2 → NP_065918.1  ubiquitin-associated protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      UniProtKB/TrEMBL
      A0A8C8KGQ8, A0A8C8MQ70
      Related
      ENSP00000354039.2, ENST00000360802.6
      Conserved Domains (2) summary
      cd14277
      Location:53 → 90
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:459 → 488
      DUF3697; Ubiquitin-associated protein 2

    RNA

    1. NR_163243.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL354989
      Related
      ENST00000629575.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33921693..34049199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33940293..34067767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001282529.1: Suppressed sequence

      Description
      NM_001282529.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_148171.1: Suppressed sequence

      Description
      NM_148171.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T6F2.1 GenPept UniProtKB/Swiss-Prot:Q5T6F2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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