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    CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 [ Homo sapiens (human) ]

    Gene ID: 10645, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CAMKK2provided by HGNC
    Official Full Name
    calcium/calmodulin dependent protein kinase kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:1470
    See related
    Ensembl:ENSG00000110931 MIM:615002; AllianceGenome:HGNC:1470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAMKK; CAMKKB
    Summary
    The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in brain (RPKM 24.4), spleen (RPKM 11.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CAMKK2 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121237692..121297819, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121228458..121289212, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121675495..121735622, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7157 Neighboring gene NANOG hESC enhancer GRCh37_chr12:121593595-121594096 Neighboring gene purinergic receptor P2X 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121627731-121628231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121661200-121661700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7159 Neighboring gene Sharpr-MPRA regulatory region 10951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121671545-121672172 Neighboring gene purinergic receptor P2X 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4971 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121683587-121683800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121693396-121693896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720271-121720878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720879-121721486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4972 Neighboring gene anaphase promoting complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121773208-121773399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121789289-121789964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121790641-121791316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121791317-121791990 Neighboring gene uncharacterized LOC124903037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7163

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex. Yu P, et al. Hum Brain Mapp, 2016 Jul. PMID 27004598, Free PMC Article
    2. Effects of Single-Nucleotide Polymorphisms in Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2): A Comprehensive Study. Khalid Z, et al. Comput Math Methods Med, 2020. PMID 33082841, Free PMC Article
    3. MiR-1271 regulates glioblastoma cell proliferation and invasion by directly targeting the CAMKK2 gene. Huang YK, et al. Neurosci Lett, 2020 Oct 15. PMID 32791096
    4. The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans. Gaff J, et al. J Neurol Sci, 2020 Sep 15. PMID 32585444
    5. Association analysis between CAMKK2 rs1063843 and patients with schizophrenia in a Han Chinese population. Qian L, et al. Asian J Psychiatr, 2020 Aug. PMID 32305031

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKbeta in diabetic kidney disease.
      Title: Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKβ in diabetic kidney disease.
    2. Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant.
      Title: Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant.
    3. CaMKK2 as an emerging treatment target for bipolar disorder.
      Title: CaMKK2 as an emerging treatment target for bipolar disorder.
    4. Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis.
      Title: Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis.
    5. Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.
      Title: Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.
    6. The role of CaMKK2 in Golgi-associated vesicle trafficking.
      Title: The role of CaMKK2 in Golgi-associated vesicle trafficking.
    7. Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.
      Title: Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.
    8. Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKbeta.
      Title: Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ.
    9. Brief Report: Polymorphisms in CAMKK2 may Influence Domain-Specific Neurocognitive Function in HIV+ Indonesians Receiving ART.
      Title: Brief Report: Polymorphisms in CAMKK2 may Influence Domain-Specific Neurocognitive Function in HIV+ Indonesians Receiving ART.
    10. CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner.
      Title: CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner.
    Submit: New GeneRIF Correction See all GeneRIFs (79)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Knockdown of calcium/calmodulin-dependent protein kinase kinase 2 beta (CAMKK2) by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0787, MGC15254

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CAMKK-AMPK signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAMKK-AMPK signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in MAPK cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in calcium-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to reactive oxygen species TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of autophagy of mitochondrion IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase kinase 2
    Names
    CAMKK beta protein
    caM-KK 2
    caM-KK beta
    caM-kinase kinase 2
    caM-kinase kinase beta
    calcium/calmodulin-dependent protein kinase beta
    calcium/calmodulin-dependent protein kinase kinase 2, beta
    NP_001257414.1
    NP_001257415.1
    NP_006540.3
    NP_705719.2
    NP_705720.1
    NP_757363.1
    NP_757364.1
    NP_757365.1
    NP_757380.1
    XP_005253879.1
    XP_005253880.1
    XP_005253881.1
    XP_011536065.1
    XP_011536066.1
    XP_016874191.1
    XP_047284057.1
    XP_047284058.1
    XP_047284059.1
    XP_047284060.1
    XP_047284061.1
    XP_047284062.1
    XP_047284063.1
    XP_047284064.1
    XP_047284065.1
    XP_054226771.1
    XP_054226772.1
    XP_054226773.1
    XP_054226774.1
    XP_054226775.1
    XP_054226776.1
    XP_054226777.1
    XP_054226778.1
    XP_054226779.1
    XP_054226780.1
    XP_054226781.1
    XP_054226782.1
    XP_054226783.1
    XP_054226784.1
    XP_054226785.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029409.1 RefSeqGene

      Range
      6600..65617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270485.2 → NP_001257414.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_001257414.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1, and encodes isoform (1). Variants 1 and 8 encode the same protein (isoform 1).
      Source sequence(s)
      AA678930, AB081336, AF287630, AL834322, BC026060, DA075361
      Consensus CDS
      CCDS9216.1
      UniProtKB/Swiss-Prot
      A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000384600.3, ENST00000404169.8
      Conserved Domains (1) summary
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    2. NM_001270486.1 → NP_001257415.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 7

      See identical proteins and their annotated locations for NP_001257415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks a segment in the 3' coding region and 3' UTR, which leads to a frameshift, compared to variant 1. The resulting isoform (7) contains a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA678930, AB018330, AF321385, AL834322
      Consensus CDS
      CCDS58283.1
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000376266.2, ENST00000392474.6
      Conserved Domains (2) summary
      smart00220
      Location:165 → 446
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    3. NM_006549.4 → NP_006540.3  calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_006540.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as beta 1, represents the longest transcript, and encodes the longest isoform (1). Variants 1 and 8 encode the same protein (isoform 1).
      Source sequence(s)
      AC069209
      Consensus CDS
      CCDS9216.1
      UniProtKB/Swiss-Prot
      A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000312741.5, ENST00000324774.9
      Conserved Domains (1) summary
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    4. NM_153499.3 → NP_705719.2  calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_705719.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as beta 1del16, lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1. This isoform (2) is also encoded by variant 7.
      Source sequence(s)
      AC069209
      Consensus CDS
      CCDS9218.1
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000336634.3, ENST00000337174.7
      Conserved Domains (1) summary
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    5. NM_153500.2 → NP_705720.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 4

      See identical proteins and their annotated locations for NP_705720.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as beta 1del14del16, has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC069209
      Consensus CDS
      CCDS9219.1
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000445944.1, ENST00000538733.5
      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    6. NM_172214.3 → NP_757363.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 5

      See identical proteins and their annotated locations for NP_757363.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as beta 2, contains an alternate segment in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC069209, AF287631
      Consensus CDS
      CCDS44999.1
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000376265.2, ENST00000392473.2
      Conserved Domains (1) summary
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    7. NM_172215.3 → NP_757364.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 6

      See identical proteins and their annotated locations for NP_757364.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as beta 2del14, differs in the 3' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (6) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC069209, AF287631
      Consensus CDS
      CCDS53837.1
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000388273.2, ENST00000446440.6
      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    8. NM_172216.2 → NP_757365.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 3

      See identical proteins and their annotated locations for NP_757365.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as beta 1del14, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC069209
      Consensus CDS
      CCDS9217.1
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000321230.3, ENST00000347034.6
      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    9. NM_172226.3 → NP_757380.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_757380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and also lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1. This isoform (2) is also encoded by variant 2.
      Source sequence(s)
      AB018330, AC069209, AI612762, BC026060, DA075361
      Consensus CDS
      CCDS9218.1
      UniProtKB/TrEMBL
      B4DV02
      Related
      ENSP00000388368.2, ENST00000412367.6
      Conserved Domains (1) summary
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      121237692..121297819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018702.3 → XP_016874191.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

      UniProtKB/TrEMBL
      B4DV02
      Conserved Domains (2) summary
      smart00220
      Location:165 → 446
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    2. XM_005253824.3 → XP_005253881.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

      See identical proteins and their annotated locations for XP_005253881.1

      UniProtKB/TrEMBL
      B4DV02
      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    3. XM_047428105.1 → XP_047284061.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6

      UniProtKB/TrEMBL
      B4DV02

    4. XM_005253822.3 → XP_005253879.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3

      See identical proteins and their annotated locations for XP_005253879.1

      UniProtKB/TrEMBL
      B4DV02
      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    5. XM_011537763.1 → XP_011536065.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_011536065.1

      UniProtKB/TrEMBL
      B4DV02
      Conserved Domains (2) summary
      smart00220
      Location:165 → 446
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    6. XM_047428107.1 → XP_047284063.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

      UniProtKB/TrEMBL
      B4DV02

    7. XM_047428103.1 → XP_047284059.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4

      UniProtKB/TrEMBL
      B4DV02

    8. XM_047428102.1 → XP_047284058.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

      UniProtKB/TrEMBL
      B4DV02

    9. XM_047428101.1 → XP_047284057.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
      UniProtKB/TrEMBL
      B4DV02

    10. XM_011537764.3 → XP_011536066.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10

      Conserved Domains (2) summary
      smart00220
      Location:9 → 282
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9 → 283
      PKc_like; Protein Kinases, catalytic domain

    11. XM_047428109.1 → XP_047284065.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X11

    12. XM_047428108.1 → XP_047284064.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9

      UniProtKB/TrEMBL
      B4DV02

    13. XM_005253823.1 → XP_005253880.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

      See identical proteins and their annotated locations for XP_005253880.1

      UniProtKB/TrEMBL
      B4DV02
      Conserved Domains (1) summary
      cd14199
      Location:162 → 447
      STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

    14. XM_047428104.1 → XP_047284060.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

      UniProtKB/TrEMBL
      B4DV02

    15. XM_047428106.1 → XP_047284062.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7

      UniProtKB/TrEMBL
      B4DV02

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      121228458..121289212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370799.1 → XP_054226774.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

      UniProtKB/TrEMBL
      B4DV02

    2. XM_054370806.1 → XP_054226781.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

      UniProtKB/TrEMBL
      B4DV02

    3. XM_054370804.1 → XP_054226779.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6

      UniProtKB/TrEMBL
      B4DV02

    4. XM_054370800.1 → XP_054226775.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      B4DV02

    5. XM_054370797.1 → XP_054226772.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

      UniProtKB/TrEMBL
      B4DV02

    6. XM_054370807.1 → XP_054226782.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

      UniProtKB/TrEMBL
      B4DV02

    7. XM_054370801.1 → XP_054226776.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4

      UniProtKB/TrEMBL
      B4DV02

    8. XM_054370798.1 → XP_054226773.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

      UniProtKB/TrEMBL
      B4DV02

    9. XM_054370796.1 → XP_054226771.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
      UniProtKB/TrEMBL
      B4DV02

    10. XM_054370809.1 → XP_054226784.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10

    11. XM_054370810.1 → XP_054226785.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X11

    12. XM_054370808.1 → XP_054226783.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9

      UniProtKB/TrEMBL
      B4DV02

    13. XM_054370802.1 → XP_054226777.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

      UniProtKB/TrEMBL
      B4DV02

    14. XM_054370803.1 → XP_054226778.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

      UniProtKB/TrEMBL
      B4DV02

    15. XM_054370805.1 → XP_054226780.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7

      UniProtKB/TrEMBL
      B4DV02
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RR4.2 GenPept UniProtKB/Swiss-Prot:Q96RR4

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