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    KIF26B kinesin family member 26B [ Homo sapiens (human) ]

    Gene ID: 55083, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIF26Bprovided by HGNC
    Official Full Name
    kinesin family member 26Bprovided by HGNC
    Primary source
    HGNC:HGNC:25484
    See related
    Ensembl:ENSG00000162849 MIM:614026; AllianceGenome:HGNC:25484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in placenta (RPKM 1.6), endometrium (RPKM 0.9) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF26B in Genome Data Viewer
    Location:
    1q44
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (245154985..245709432)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (244572450..245130184)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (245318287..245872734)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245316423-245317098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245317099-245317774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245343249-245343749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245342748-245343248 Neighboring gene RNA, U1 small nuclear 132, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:245358334-245359141 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:245366003-245366213 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:245376557-245377756 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:245397844-245398363 Neighboring gene KIF26B antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:245419187-245420056 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245420057-245420924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245421793-245422660 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:245474556-245474731 Neighboring gene Sharpr-MPRA regulatory region 12100 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 8 Neighboring gene NANOG hESC enhancer GRCh37_chr1:245629563-245630064 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:245630817-245632016 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:245647215-245647978 Neighboring gene uncharacterized LOC124904571 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:245746285-245747484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245769345-245770175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245774720-245775220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245775221-245775721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245786008-245786527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245811797-245812310 Neighboring gene uncharacterized LOC105373265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245874821-245875320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245874319-245874820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245878266-245878766 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:245926173-245926700 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245937857-245938697 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245938698-245939538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245979520-245980135 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245980136-245980750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246016290-246016790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246016791-246017291 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:246032999-246034198 Neighboring gene SET and MYND domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246111472-246111972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246226795-246227321 Neighboring gene NANOG hESC enhancer GRCh37_chr1:246228833-246229369 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246273353-246273854 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246273855-246274354 Neighboring gene Sharpr-MPRA regulatory region 4643 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:246302792-246303991 Neighboring gene CRISPRi-validated SMYD3 hub enhancer Neighboring gene SMYD3 antisense RNA 1 Neighboring gene CRISPRi-validated SMYD3 non-hub enhancer Neighboring gene CRISPR perturbation-validated SMYD3 cis-regulatory element TAD4.SE2.HS8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2030 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis. Huang LM, et al. World J Gastroenterol, 2024 May 28. PMID 38855156, Free PMC Article
    2. KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer. Zhang H, et al. Oncogene, 2017 Oct 5. PMID 28581513
    3. MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene. Pu Y, et al. Cancer Cell Int, 2016. PMID 27499703, Free PMC Article
    4. Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis. Yang X, et al. Med Sci Monit, 2018 Jun 8. PMID 29880787, Free PMC Article
    5. De novo variant in KIF26B is associated with pontocerebellar hypoplasia with infantile spinal muscular atrophy. Wojcik MH, et al. Am J Med Genet A, 2018 Dec. PMID 30151950, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of KIF26B as a Tumor Marker for Oral Squamous Cell Carcinoma.
      Title: Identification of KIF26B as a Tumor Marker for Oral Squamous Cell Carcinoma.
    2. Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis.
      Title: Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis.
    3. KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer.
      Title: KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer.
    4. Noncoding RNAs-based high KIF26B expression correlates with poor prognosis and tumor immune infiltration in colon cancer.
      Title: Noncoding RNAs-based high KIF26B expression correlates with poor prognosis and tumor immune infiltration in colon cancer.
    5. Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
      Title: Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
    6. The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification.
      Title: The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification.
    7. KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway.
      Title: KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway.
    8. ELK1-induced up-regulation of KIF26B promotes cell cycle progression in breast cancer.
      Title: ELK1-induced up-regulation of KIF26B promotes cell cycle progression in breast cancer.
    9. Our results did prove a statistical association of both rs2228557 and rs12407427 genotypes (TT and CT + CC) and allele (T) with KTCN susceptibility in Iranian population.
      Title: Association of KIF26B and COL4A4 gene polymorphisms with the risk of keratoconus in a sample of Iranian population.
    10. KIF26B may play a critical role in the brain development and, when mutated, cause pontocerebellar hypoplasia with arthrogryposis.
      Title: De novo variant in KIF26B is associated with pontocerebellar hypoplasia with infantile spinal muscular atrophy.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV Vif interacts with KIF26B PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10157, MGC35030

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ureteric bud invasion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF26B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053061.1 RefSeqGene

      Range
      5001..559448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018012.4 → NP_060482.2  kinesin-like protein KIF26B

      See identical proteins and their annotated locations for NP_060482.2

      Status: REVIEWED

      Source sequence(s)
      AC104462, AY923834
      Consensus CDS
      CCDS44342.1
      UniProtKB/Swiss-Prot
      Q2KJY2, Q6ZQR9, Q6ZUZ0, Q8IUN3, Q8IVR1, Q9NWB4
      UniProtKB/TrEMBL
      A0A0G2JR66
      Related
      ENSP00000385545.2, ENST00000407071.7
      Conserved Domains (2) summary
      smart00129
      Location:451 → 798
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:450 → 798
      KISc; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      245154985..245709432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187516.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      46767..407457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017030182.2 → XP_016885671.1  kinesin-like protein KIF26B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JR66
      Conserved Domains (2) summary
      smart00129
      Location:251 → 598
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:250 → 598
      KISc; Kinesin motor domain

    2. XM_017030183.1 → XP_016885672.1  kinesin-like protein KIF26B isoform X2

      UniProtKB/TrEMBL
      A0A0G2JR66, B7WPD9
      Conserved Domains (2) summary
      smart00129
      Location:70 → 417
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:69 → 417
      KISc; Kinesin motor domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      244572450..245130184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KJY2.1 GenPept UniProtKB/Swiss-Prot:Q2KJY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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